Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration

To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. A review of English literature on childhood ALL focusing on collaborative studies was performed. The resulting article was reviewed and revised by...

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Vydáno v:Journal of clinical oncology Ročník 33; číslo 27; s. 2938
Hlavní autoři: Pui, Ching-Hon, Yang, Jun J, Hunger, Stephen P, Pieters, Rob, Schrappe, Martin, Biondi, Andrea, Vora, Ajay, Baruchel, André, Silverman, Lewis B, Schmiegelow, Kjeld, Escherich, Gabriele, Horibe, Keizo, Benoit, Yves C M, Izraeli, Shai, Yeoh, Allen Eng Juh, Liang, Der-Cherng, Downing, James R, Evans, William E, Relling, Mary V, Mullighan, Charles G
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 20.09.2015
Témata:
Adolescent
Age of Onset
Biomarkers, Tumor - genetics
Child
Child, Preschool
Cooperative Behavior
Diffusion of Innovation
Genetic Predisposition to Disease
Genetic Testing
History, 20th Century
History, 21st Century
Humans
Infant
Infant, Newborn
Interdisciplinary Communication
International Cooperation
Medical Oncology - trends
Pediatrics - trends
Phenotype
Precision Medicine
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Predictive Value of Tests
Survivors
Time Factors
Treatment Outcome
ISSN:1527-7755, 1527-7755
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Popis
Shrnutí:To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. A review of English literature on childhood ALL focusing on collaborative studies was performed. The resulting article was reviewed and revised by the committee chairs of the major ALL study groups. With long-term survival rates for ALL approaching 90% and the advent of high-resolution genome-wide analyses, several international study groups or consortia were established to conduct collaborative research to further improve outcome. As a result, treatment strategies have been improved for several subtypes of ALL, such as infant, MLL-rearranged, Philadelphia chromosome-positive, and Philadelphia chromosome-like ALL. Many recurrent genetic abnormalities that respond to tyrosine kinase inhibitors and multiple genetic determinants of drug resistance and toxicities have been identified to help develop targeted therapy. Several genetic polymorphisms have been recognized that show susceptibility to developing ALL and that help explain the racial/ethnic differences in the incidence of ALL. The information gained from collaborative studies has helped decipher the heterogeneity of ALL to help improve personalized treatment, which will further advance the current high cure rate and the quality of life for children and adolescents with ALL.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1527-7755
1527-7755
DOI:10.1200/JCO.2014.59.1636