Extended two-stage adaptive designs with three target responses for phase II clinical trials

We develop a nature-inspired stochastic population-based algorithm and call it discrete particle swarm optimization to find extended two-stage adaptive optimal designs that allow three target response rates for the drug in a phase II trial. Our proposed designs include the celebrated Simon's tw...

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Vydáno v:	Statistical methods in medical research Ročník 27; číslo 12; s. 3628
Hlavní autoři:	Kim, Seongho, Wong, Weng Kee
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.12.2018
Témata:	Adaptive Clinical Trials as Topic Algorithms Clinical Trials, Phase II as Topic Humans Melanoma - drug therapy Models, Statistical Research Design Sample Size sequential design Adaptive design Simon’s two-stage design particle swarm optimization power greedy algorithm
ISSN:	1477-0334, 1477-0334
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