Left ventricular hypertrophy and hypertension

Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertr...

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Veröffentlicht in:	Progress in cardiovascular diseases Jg. 63; H. 1; S. 10 - 21
Hauptverfasser:	Yildiz, Mehmet, Oktay, Ahmet Afşin, Stewart, Merrill H., Milani, Richard V., Ventura, Hector O., Lavie, Carl J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.01.2020
Schlagworte:	Anti-hypertension therapy Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Cardiovascular Humans Hypertension Hypertension - diagnosis Hypertension - mortality Hypertension - physiopathology Hypertension - therapy Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - mortality Hypertrophy, Left Ventricular - physiopathology Hypertrophy, Left Ventricular - prevention & control Left ventricular geometry Left ventricular hypertrophy Remodeling Risk Factors Risk Reduction Behavior Treatment Outcome Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects MESA RCT HTN MRI STE RAAS DM LV Remodeling BP CCBs CACS 2D ASE CHIP ESC ARIC cLVH eLVH ESH Anti-hypertension therapy MI CKD HOPE LIFE SBP Hypertension ACC EF ACE AF SGLT2 ALLHAT CAD ECG Left ventricular geometry RWT CR CVD EACVI 3D HCM SCD Left ventricular hypertrophy AHA ARBs HF LVH Myocardial infarction Randomized clinical trial Angiotensin receptor blockers European Society of Hypertension Cardiovascular disease Left ventricle/ventricular Calcium channel blockers Electrocardiography Blood pressure Renin-angiotensin-aldosterone system Concentric left ventricular hypertrophy Sodium-glucose cotransporter type2 Heart failure Systolic blood pressure American College of Cardiology American Heart Association Multiethnic Study of Atherosclerosis Angiotensin converting enzyme Losartan Intervention for Endpoint Reduction Hypertrophic cardiomyopathy American Society of Echocardiography Ejection fraction Atherosclerosis Risk in Communities Heart Outcomes Prevention Evaluation Eccentric left ventricular hypertrophy European Association of Cardiovascular Imaging Two-dimensional Relative wall thickness Chlorthalidone, indapamide, and potassium-sparing diuretic/hydrochlorothiazide Coronary artery calcium scoring Atrial fibrillation Concentric remodeling Diabetes mellitus Speckle tracking echocardiography Chronic kidney disease Sudden cardiac death Coronary artery disease Hypertension or hypertensive European Society of Cardiology Magnetic resonance imaging Three-dimensional Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack
ISSN:	0033-0620, 1873-1740, 1532-8643, 1873-1740
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Beschreibung
Zusammenfassung:	Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0033-0620 1873-1740 1532-8643 1873-1740
DOI:	10.1016/j.pcad.2019.11.009