Left ventricular hypertrophy and hypertension

Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertr...

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Vydáno v:Progress in cardiovascular diseases Ročník 63; číslo 1; s. 10 - 21
Hlavní autoři: Yildiz, Mehmet, Oktay, Ahmet Afşin, Stewart, Merrill H., Milani, Richard V., Ventura, Hector O., Lavie, Carl J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.01.2020
Témata:
RCT
HTN
MRI
STE
DM
LV
BP
2D
ASE
ESC
ESH
MI
CKD
SBP
ACC
EF
ACE
AF
CAD
ECG
RWT
CR
CVD
3D
HCM
SCD
AHA
HF
LVH
ISSN:0033-0620, 1873-1740, 1532-8643, 1873-1740
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Abstract Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches.
AbstractList Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches.
AbstractHypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches.
Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches.Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches.
Author Milani, Richard V.
Stewart, Merrill H.
Yildiz, Mehmet
Oktay, Ahmet Afşin
Lavie, Carl J.
Ventura, Hector O.
Author_xml – sequence: 1
  givenname: Mehmet
  surname: Yildiz
  fullname: Yildiz, Mehmet
  organization: Department of Medicine, Southern Ohio Medical Center, Portsmouth, OH, United States of America
– sequence: 2
  givenname: Ahmet Afşin
  surname: Oktay
  fullname: Oktay, Ahmet Afşin
  email: ahmet.oktay@wdhospital.org
  organization: Department of Medicine, Division of Cardiology, Wentworth-Douglass Hospital, Partners HealthCare, Dover, NH, United States of America
– sequence: 3
  givenname: Merrill H.
  surname: Stewart
  fullname: Stewart, Merrill H.
  organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America
– sequence: 4
  givenname: Richard V.
  surname: Milani
  fullname: Milani, Richard V.
  organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America
– sequence: 5
  givenname: Hector O.
  surname: Ventura
  fullname: Ventura, Hector O.
  organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America
– sequence: 6
  givenname: Carl J.
  surname: Lavie
  fullname: Lavie, Carl J.
  organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31759953$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords MESA
RCT
HTN
MRI
STE
RAAS
DM
LV
Remodeling
BP
CCBs
CACS
2D
ASE
CHIP
ESC
ARIC
cLVH
eLVH
ESH
Anti-hypertension therapy
MI
CKD
HOPE
LIFE
SBP
Hypertension
ACC
EF
ACE
AF
SGLT2
ALLHAT
CAD
ECG
Left ventricular geometry
RWT
CR
CVD
EACVI
3D
HCM
SCD
Left ventricular hypertrophy
AHA
ARBs
HF
LVH
Myocardial infarction
Randomized clinical trial
Angiotensin receptor blockers
European Society of Hypertension
Cardiovascular disease
Left ventricle/ventricular
Calcium channel blockers
Electrocardiography
Blood pressure
Renin-angiotensin-aldosterone system
Concentric left ventricular hypertrophy
Sodium-glucose cotransporter type2
Heart failure
Systolic blood pressure
American College of Cardiology
American Heart Association
Multiethnic Study of Atherosclerosis
Angiotensin converting enzyme
Losartan Intervention for Endpoint Reduction
Hypertrophic cardiomyopathy
American Society of Echocardiography
Ejection fraction
Atherosclerosis Risk in Communities
Heart Outcomes Prevention Evaluation
Eccentric left ventricular hypertrophy
European Association of Cardiovascular Imaging
Two-dimensional
Relative wall thickness
Chlorthalidone, indapamide, and potassium-sparing diuretic/hydrochlorothiazide
Coronary artery calcium scoring
Atrial fibrillation
Concentric remodeling
Diabetes mellitus
Speckle tracking echocardiography
Chronic kidney disease
Sudden cardiac death
Coronary artery disease
Hypertension or hypertensive
European Society of Cardiology
Magnetic resonance imaging
Three-dimensional
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack
Language English
License Copyright © 2019 Elsevier Inc. All rights reserved.
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PublicationTitle Progress in cardiovascular diseases
PublicationTitleAlternate Prog Cardiovasc Dis
PublicationYear 2020
Publisher Elsevier Inc
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Snippet Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for...
AbstractHypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary...
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SubjectTerms Anti-hypertension therapy
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Cardiovascular
Humans
Hypertension
Hypertension - diagnosis
Hypertension - mortality
Hypertension - physiopathology
Hypertension - therapy
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - mortality
Hypertrophy, Left Ventricular - physiopathology
Hypertrophy, Left Ventricular - prevention & control
Left ventricular geometry
Left ventricular hypertrophy
Remodeling
Risk Factors
Risk Reduction Behavior
Treatment Outcome
Ventricular Function, Left - drug effects
Ventricular Remodeling - drug effects
Title Left ventricular hypertrophy and hypertension
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https://dx.doi.org/10.1016/j.pcad.2019.11.009
https://www.ncbi.nlm.nih.gov/pubmed/31759953
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Volume 63
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