Left ventricular hypertrophy and hypertension
Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertr...
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| Vydáno v: | Progress in cardiovascular diseases Ročník 63; číslo 1; s. 10 - 21 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Elsevier Inc
01.01.2020
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| Témata: | |
| ISSN: | 0033-0620, 1873-1740, 1532-8643, 1873-1740 |
| On-line přístup: | Získat plný text |
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| Abstract | Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches. |
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| AbstractList | Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches. AbstractHypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches. Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches.Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches. |
| Author | Milani, Richard V. Stewart, Merrill H. Yildiz, Mehmet Oktay, Ahmet Afşin Lavie, Carl J. Ventura, Hector O. |
| Author_xml | – sequence: 1 givenname: Mehmet surname: Yildiz fullname: Yildiz, Mehmet organization: Department of Medicine, Southern Ohio Medical Center, Portsmouth, OH, United States of America – sequence: 2 givenname: Ahmet Afşin surname: Oktay fullname: Oktay, Ahmet Afşin email: ahmet.oktay@wdhospital.org organization: Department of Medicine, Division of Cardiology, Wentworth-Douglass Hospital, Partners HealthCare, Dover, NH, United States of America – sequence: 3 givenname: Merrill H. surname: Stewart fullname: Stewart, Merrill H. organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America – sequence: 4 givenname: Richard V. surname: Milani fullname: Milani, Richard V. organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America – sequence: 5 givenname: Hector O. surname: Ventura fullname: Ventura, Hector O. organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America – sequence: 6 givenname: Carl J. surname: Lavie fullname: Lavie, Carl J. organization: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31759953$$D View this record in MEDLINE/PubMed |
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| Keywords | MESA RCT HTN MRI STE RAAS DM LV Remodeling BP CCBs CACS 2D ASE CHIP ESC ARIC cLVH eLVH ESH Anti-hypertension therapy MI CKD HOPE LIFE SBP Hypertension ACC EF ACE AF SGLT2 ALLHAT CAD ECG Left ventricular geometry RWT CR CVD EACVI 3D HCM SCD Left ventricular hypertrophy AHA ARBs HF LVH Myocardial infarction Randomized clinical trial Angiotensin receptor blockers European Society of Hypertension Cardiovascular disease Left ventricle/ventricular Calcium channel blockers Electrocardiography Blood pressure Renin-angiotensin-aldosterone system Concentric left ventricular hypertrophy Sodium-glucose cotransporter type2 Heart failure Systolic blood pressure American College of Cardiology American Heart Association Multiethnic Study of Atherosclerosis Angiotensin converting enzyme Losartan Intervention for Endpoint Reduction Hypertrophic cardiomyopathy American Society of Echocardiography Ejection fraction Atherosclerosis Risk in Communities Heart Outcomes Prevention Evaluation Eccentric left ventricular hypertrophy European Association of Cardiovascular Imaging Two-dimensional Relative wall thickness Chlorthalidone, indapamide, and potassium-sparing diuretic/hydrochlorothiazide Coronary artery calcium scoring Atrial fibrillation Concentric remodeling Diabetes mellitus Speckle tracking echocardiography Chronic kidney disease Sudden cardiac death Coronary artery disease Hypertension or hypertensive European Society of Cardiology Magnetic resonance imaging Three-dimensional Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack |
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| Snippet | Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for... AbstractHypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary... |
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| SubjectTerms | Anti-hypertension therapy Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Cardiovascular Humans Hypertension Hypertension - diagnosis Hypertension - mortality Hypertension - physiopathology Hypertension - therapy Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - mortality Hypertrophy, Left Ventricular - physiopathology Hypertrophy, Left Ventricular - prevention & control Left ventricular geometry Left ventricular hypertrophy Remodeling Risk Factors Risk Reduction Behavior Treatment Outcome Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects |
| Title | Left ventricular hypertrophy and hypertension |
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