International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions

Background: There has been tremendous growth in research in pediatric multiple sclerosis (MS) and immune mediated central nervous system demyelinating disorders since operational definitions for these conditions were first proposed in 2007. Further, the International Pediatric Multiple Sclerosis Stu...

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Veröffentlicht in:Multiple sclerosis Jg. 19; H. 10; S. 1261 - 1267
Hauptverfasser: Krupp, Lauren B, Tardieu, Marc, Amato, Maria Pia, Banwell, Brenda, Chitnis, Tanuja, Dale, Russell C, Ghezzi, Angelo, Hintzen, Rogier, Kornberg, Andrew, Pohl, Daniela, Rostasy, Kevin, Tenembaum, Silvia, Wassmer, Evangeline
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London, England SAGE Publications 01.09.2013
Sage Publications
Sage Publications Ltd
Schlagworte:
Biological and medical sciences
Child
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Demyelinating Autoimmune Diseases, CNS - diagnosis
Encephalomyelitis, Acute Disseminated - diagnosis
Humans
Medical sciences
Multiple Sclerosis - diagnosis
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Neuromyelitis Optica - diagnosis
Pediatrics - standards
acute disseminated encephalomyelitis
childhood multiple sclerosis
pediatric multiple sclerosis
Multiple sclerosis
clinically isolated syndrome
neuromyelitis optica
Human
Pediatrics
Nervous system diseases
Optic nerve
Encephalomyelitis
Central nervous system
Neurooptic myelitis
Inflammatory disease
Cerebral disorder
Eye disease
Cranial nerve disease
Visual pathway
Revision
Central nervous system disease
Degenerative disease
Spinal cord disease
Child
Immune system
ISSN:1352-4585, 1477-0970, 1477-0970
Online-Zugang:Volltext
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Zusammenfassung:Background: There has been tremendous growth in research in pediatric multiple sclerosis (MS) and immune mediated central nervous system demyelinating disorders since operational definitions for these conditions were first proposed in 2007. Further, the International Pediatric Multiple Sclerosis Study Group (IPMSSG), which proposed the criteria, has expanded substantially in membership and in its international scope. Objective: The purpose of this review is to revise the 2007 definitions in order to incorporate advances in delineating the clinical and neuroradiologic features of these disorders. Methods: Through a consensus process, in which input was sought from the 150 members of the Study Group, criteria were drafted, revised and finalized. Final approval was sought through a web survey. Results: Revised criteria are proposed for pediatric acute disseminated encephalomyelitis, pediatric clinically isolated syndrome, pediatric neuromyelitis optica and pediatric MS. These criteria were approved by 93% or more of the 56 Study Group members who responded to the final survey. Conclusions: These definitions are proposed for clinical and research purposes. Their utility will depend on the outcomes of their application in prospective research.
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ISSN:1352-4585
1477-0970
1477-0970
DOI:10.1177/1352458513484547