The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes

This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Anais da Academia Brasileira de Ciências Ročník 93; číslo 3; s. e20201850
Hlavní autoři: MIATMOKO, ANDANG, HARIAWAN, BERLIAN S., CAHYANI, DEVY M., SARI, RETNO, DINARYANTI, ARISTIKA, HENDRIANTO, ERYK
Médium: Journal Article
Jazyk:angličtina
Vydáno: Brazil Academia Brasileira de Ciências 01.01.2021
Témata:
cancer
cell uptake
Chitosan
Chitosan - toxicity
cytotoxicity
HeLa Cells
Humans
Liposomes
MULTIDISCIPLINARY SCIENCES
niosomes
Triterpenes - pharmacology
Ursolic Acid
niosomes
cancer
Chitosan
cytotoxicity
cell uptake
ursolic acid
ISSN:0001-3765, 1678-2690, 1678-2690
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher cytotoxicity in HeLa cells than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, chitosan layers improved the cellular uptake, which clathrin-mediated endocytosis may determine the cellular transport of UA niosomes. In conclusion, the addition of chitosan improved cellular uptake and cytotoxicity of UA niosomes in the HeLa cells.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202120201850