The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes

This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher...

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Published in:Anais da Academia Brasileira de Ciências Vol. 93; no. 3; p. e20201850
Main Authors: MIATMOKO, ANDANG, HARIAWAN, BERLIAN S., CAHYANI, DEVY M., SARI, RETNO, DINARYANTI, ARISTIKA, HENDRIANTO, ERYK
Format: Journal Article
Language:English
Published: Brazil Academia Brasileira de Ciências 01.01.2021
Subjects:
cancer
cell uptake
Chitosan
Chitosan - toxicity
cytotoxicity
HeLa Cells
Humans
Liposomes
MULTIDISCIPLINARY SCIENCES
niosomes
Triterpenes - pharmacology
Ursolic Acid
niosomes
cancer
Chitosan
cytotoxicity
cell uptake
ursolic acid
ISSN:0001-3765, 1678-2690, 1678-2690
Online Access:Get full text
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Summary:This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher cytotoxicity in HeLa cells than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, chitosan layers improved the cellular uptake, which clathrin-mediated endocytosis may determine the cellular transport of UA niosomes. In conclusion, the addition of chitosan improved cellular uptake and cytotoxicity of UA niosomes in the HeLa cells.
Bibliography:ObjectType-Article-1
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ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202120201850