Evaluation of a hydrophilic interaction liquid chromatography design space for sugars and sugar alcohols

•A novel HILIC design space for analysis of sugars and sugar alcohols is described.•Aerosol detectors were used for the analysis of sugars and sugar alcohols.•A novel algorithm for analysis of design space data is presented.•Use of the algorithm for efficient method development is demonstrated.•Appl...

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Bibliographic Details
Published in:	Journal of Chromatography A Vol. 1489; pp. 65 - 74
Main Authors:	Hetrick, Evan M., Kramer, Timothy T., Risley, Donald S.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 17.03.2017
Subjects:	acetone acetonitrile aerosols Algorithms CAD Carbohydrate Carbohydrates - analysis Carbohydrates - isolation & purification Chromatography, High Pressure Liquid - methods computer software detection limit detectors ELSD glucose HILIC hydrophilic interaction chromatography Hydrophobic and Hydrophilic Interactions light scattering quantitative analysis Solvents - chemistry Sugar Sugar alcohols Sugar Alcohols - analysis Sugar Alcohols - isolation & purification trehalose ELSD Sugar alcohols Carbohydrate HILIC Sugar CAD
ISSN:	0021-9673, 1873-3778, 1873-3778
Online Access:	Get full text
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