Comprehensive 4D robustness evaluation for pencil beam scanned proton plans

Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evalua...

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Veröffentlicht in:Radiotherapy and oncology Jg. 136; S. 185 - 189
Hauptverfasser: Ribeiro, Cássia O., Meijers, Arturs, Korevaar, Erik W., Muijs, Christina T., Both, Stefan, Langendijk, Johannes A., Knopf, Antje
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Ireland Elsevier B.V 01.07.2019
Schlagworte:
4D robustness evaluation
Esophageal Neoplasms - diagnostic imaging
Esophageal Neoplasms - radiotherapy
Four-Dimensional Computed Tomography - methods
Humans
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - radiotherapy
Moving targets
Oesophagus cancer
Pencil beam scanned proton therapy
Proton Therapy - methods
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Voxel-wise worst-case dose
Moving targets
Pencil beam scanned proton therapy
4D robustness evaluation
Voxel-wise worst-case dose
Lung cancer
Oesophagus cancer
ISSN:0167-8140, 1879-0887, 1879-0887
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select and apply motion mitigation techniques.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0167-8140
1879-0887
1879-0887
DOI:10.1016/j.radonc.2019.03.037