Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development

Mutations in the transcription factor TBX20 are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by E9.5. As Tbx20 is expressed in multiple cell lineages required for myocardial development, including pharyngeal endode...

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Vydané v:	Circulation research Ročník 123; číslo 4; s. 428
Hlavní autori:	Boogerd, Cornelis J, Zhu, Xiaoming, Aneas, Ivy, Sakabe, Noboru J, Zhang, Lunfeng, Sobreira, Debora R, Montefiori, Lindsey E, Bogomolovas, Julius, Joslin, Amelia C, Zhou, Bin, Chen, Ju, Nobrega, Marcelo, Evans, Sylvia M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 03.08.2018
Predmet:	cardiomyocyte differentiation congenital heart disease heart development transcriptional regulation chamber specification
ISSN:	1524-4571, 1524-4571
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