Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable...

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Vydané v:	Cell Ročník 166; číslo 3; s. 609
Hlavní autori:	Joyce, M Gordon, Wheatley, Adam K, Thomas, Paul V, Chuang, Gwo-Yu, Soto, Cinque, Bailer, Robert T, Druz, Aliaksandr, Georgiev, Ivelin S, Gillespie, Rebecca A, Kanekiyo, Masaru, Kong, Wing-Pui, Leung, Kwanyee, Narpala, Sandeep N, Prabhakaran, Madhu S, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Asokan, Mangaiarkarasi, Boyington, Jeffrey C, Bylund, Tatsiana, Darko, Sam, Lees, Christopher R, Ransier, Amy, Shen, Chen-Hsiang, Wang, Lingshu, Whittle, James R, Wu, Xueling, Yassine, Hadi M, Santos, Celia, Matsuoka, Yumiko, Tsybovsky, Yaroslav, Baxa, Ulrich, Mullikin, James C, Subbarao, Kanta, Douek, Daniel C, Graham, Barney S, Koup, Richard A, Ledgerwood, Julie E, Roederer, Mario, Shapiro, Lawrence, Kwong, Peter D, Mascola, John R, McDermott, Adrian B
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 28.07.2016
Predmet:	Adult Amino Acid Sequence Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - genetics Antibodies, Viral - immunology B-Lymphocytes - immunology Epitopes, B-Lymphocyte Female Gene Rearrangement, B-Lymphocyte, Heavy Chain Humans Immunologic Memory Influenza A virus - immunology Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - immunology Male Middle Aged Models, Molecular Protein Structure, Tertiary Structure-Activity Relationship Young Adult
ISSN:	1097-4172, 1097-4172
On-line prístup:	Zistit podrobnosti o prístupe
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