Frailty and Cardiovascular Health

The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic ma...

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Published in:Journal of the American Heart Association Vol. 13; no. 15; p. e031736
Main Authors: James, Kirstyn, Jamil, Yasser, Kumar, Manish, Kwak, Min J., Nanna, Michael G., Qazi, Saadia, Troy, Aaron L., Butt, Jawad H., Damluji, Abdulla A., Forman, Daniel E., Orkaby, Ariela R.
Format: Journal Article
Language:English
Published: England John Wiley and Sons Inc 06.08.2024
Wiley
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ISSN:2047-9980, 2047-9980
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Summary:The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD.
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K. James and Y. Jamil are co‐first authors.
For Sources of Funding and Disclosures, see page 15.
This article was sent to Tiffany M. Powell‐Wiley, MD, MPH, Associate Editor, for review by expert referees, editorial decision, and final disposition.
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.123.031736