Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

Imidazo[1,2-a]pyridines (IPs) have been studied regarding drug development. The objective of this work was to evaluate the antileukemic capacity of IP derivatives by screening their ability as a pro-oxidant. IP derivatives were synthesized and oral bioavailability and toxicity were analyzed in silic...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Jg. 28; H. 2; S. 893
Hauptverfasser:	Burkner, Gabriella Teles, Dias, Dhébora Albuquerque, Souza, Kamylla Fernanda Souza de, Araújo, Anna Júlia Papa de, Basilio, Denise Caroline Luiz Soares, Jacobsen, Fernanda Tondello, Moraes, Ana Carolina Rabello de, Silva-Filho, Saulo Euclides, Cavalcante, Marcos Filipe de Oliveira, Moraes, Cassio Augusto de Oliveira, Saba, Sumbal, Macedo, Maria Lígia Rodrigues, Paredes-Gamero, Edgar Julian, Rafique, Jamal, Parisotto, Eduardo Benedetti
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 01.01.2023 MDPI
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Bioavailability Breast cancer Cancer therapies Cell cycle Cell growth Cell Proliferation Cellular Senescence Chemotherapy chronic myeloid leukemia DNA damage Drug development Humans imidazo[1,2-a]pyridines K562 Cells Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myeloid Oxidative Stress Pyridines - pharmacology selenide Senescence Toxicity senescence leukemia chronic myeloid leukemia imidazo[1,2-a]pyridines selenide oxidative stress
ISSN:	1420-3049, 1420-3049
Online-Zugang:	Volltext
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