Population pharmacokinetics of busulfan in pediatric and young adult patients undergoing hematopoietic cell transplant: a model-based dosing algorithm for personalized therapy and implementation into routine clinical use

Population pharmacokinetic (PK) studies of busulfan in children have shown that individualized model-based algorithms provide improved targeted busulfan therapy when compared with conventional dose guidelines. The adoption of population PK models into routine clinical practice has been hampered by t...

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Bibliographic Details
Published in:	Therapeutic drug monitoring Vol. 37; no. 2; p. 236
Main Authors:	Long-Boyle, Janel R, Savic, Rada, Yan, Shirley, Bartelink, Imke, Musick, Lisa, French, Deborah, Law, Jason, Horn, Biljana, Cowan, Morton J, Dvorak, Christopher C
Format:	Journal Article
Language:	English
Published:	United States 01.04.2015
Subjects:	Adolescent Age Factors Algorithms Busulfan - administration & dosage Busulfan - pharmacokinetics Child Child, Preschool Female Hematopoietic Stem Cell Transplantation Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Infant Male Models, Biological Nonlinear Dynamics Precision Medicine Retrospective Studies Young Adult
ISSN:	1536-3694, 1536-3694
Online Access:	Get more information
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