Prenatal Exposure to Perfluoroalkyl Substances and Adiposity in Early and Mid-Childhood

Few studies have examined whether prenatal exposure to perfluoroalkyl substances (PFASs) is associated with childhood adiposity. We examined associations of prenatal exposure to PFASs with adiposity in early and mid-childhood. We measured plasma PFAS concentrations in 1,645 pregnant women (median, 9...

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Bibliographic Details
Published in:Environmental health perspectives Vol. 125; no. 3; pp. 467 - 473
Main Authors: Mora, Ana María, Oken, Emily, Rifas-Shiman, Sheryl L., Webster, Thomas F., Gillman, Matthew W., Calafat, Antonia M., Ye, Xiaoyun, Sagiv, Sharon K.
Format: Journal Article
Language:English
Published: United States National Institute of Environmental Health Sciences 01.03.2017
Subjects:
Adiposity - physiology
Age
Alkanesulfonic Acids
Body composition
Body fat
Body mass index
Caprylates
Child, Preschool
Children
Children & youth
Cohort analysis
Creatinine
Disease control
Environmental Pollutants - blood
Exposure
Female
Fluorocarbons - blood
Food contamination & poisoning
Gender differences
Girls
Health risk assessment
Hemodynamics
Humans
Male
Massachusetts
Maternal Exposure - statistics & numerical data
Medical laboratories
Obesity
Obesity - epidemiology
Overweight
Perfluoroalkyl & polyfluoroalkyl substances
Plasma
Pregnancy
Prenatal exposure
Questionnaires
Studies
Sulfonates
Womens health
United States > US
ISSN:0091-6765, 1552-9924, 1552-9924
Online Access:Get full text
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Summary:Few studies have examined whether prenatal exposure to perfluoroalkyl substances (PFASs) is associated with childhood adiposity. We examined associations of prenatal exposure to PFASs with adiposity in early and mid-childhood. We measured plasma PFAS concentrations in 1,645 pregnant women (median, 9.6 weeks gestation) enrolled in Project Viva, a prospective pre-birth cohort study in Massachusetts (USA), between 1999 and 2002. We assessed overall and central adiposity in 1,006 children in early childhood (median, 3.2 years) and 876 in mid-childhood (median, 7.7 years) using anthropometric and dual X-ray absorptiometry (DXA) measurements. We fitted multivariable linear regression models to estimate exposure-outcome associations and evaluated effect modification by child sex. Median (25-75th percentiles) prenatal plasma perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) concentrations in children assessed in early childhood were 5.6 (4.1-7.7), 24.8 (18.4-33.9), 2.4 (1.6-3.8), and 0.6 (0.5-0.9) ng/mL, respectively. Among girls, each interquartile range increment of prenatal PFOA concentrations was associated with 0.21 kg/m (95% CI: -0.05, 0.48) higher body mass index, 0.76 mm (95% CI: -0.17, 1.70) higher sum of subscapular and triceps skinfold thickness, and 0.17 kg/m (95% CI: -0.02, 0.36) higher DXA total fat mass index in mid-childhood. Similar associations were observed for PFOS, PFHxS, and PFNA. We observed null associations for boys and early-childhood adiposity measures. In this cohort, prenatal exposure to PFASs was associated with small increases in adiposity measurements in mid-childhood, but only among girls. Citation: Mora AM, Oken E, Rifas-Shiman SL, Webster TF, Gillman MW, Calafat AM, Ye X, Sagiv SK. 2017. Prenatal exposure to perfluoroalkyl substances and adiposity in early and mid-childhood. Environ Health Perspect 125:467-473; http://dx.doi.org/10.1289/EHP246.
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ISSN:0091-6765
1552-9924
1552-9924
DOI:10.1289/EHP246