Association between − 308 tumour necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma

Background Tumour necrosis factor (TNF) is a pivotal cytokine in the inflammation underlying asthma. The TNF gene is located in the polymorphic HLA class 3 region on chromosome 6p. Several polymorphisms in this region have been described and associated with alteration of TNF secretion in vitro. Obje...

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Bibliographic Details
Published in:	Clinical and experimental allergy Vol. 29; no. 9; pp. 1204 - 1208
Main Authors:	LI KAM WA, T. C, MANSUR, A. H, BRITTON, J, WILLIAMS, G, PAVORD, I, RICHARDS, K, CAMPBELL, D. A, MORTON, N, HOLGATE, S. T, MORRISON, J. F. J
Format:	Journal Article
Language:	English
Published:	Oxford BSL Blackwell Science Ltd 01.09.1999 Blackwell
Subjects:	Adolescent Adult Aged asthma Asthma - genetics Asthma - physiopathology Biological and medical sciences bronchial hyperreactivity Bronchial Hyperreactivity - genetics Chromosomes, Human, Pair 6 Chronic obstructive pulmonary disease, asthma Genetic Linkage Genetic Predisposition to Disease genetics Haplotypes Histocompatibility Testing Humans Lymphotoxin-alpha - genetics Medical sciences Pneumology Polymorphism, Genetic Promoter Regions, Genetic Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics tumour necrosis factor Human Hyperreactivity Respiratory disease Cytokine Bronchus Genetic determinism Asthma Promoter Gene Tumor necrosis factor Cohort study Risk factor Genetics Obstructive pulmonary disease Polymorphism
ISSN:	0954-7894, 1365-2222
Online Access:	Get full text
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