Menopausal hot flashes: Mechanisms, endocrinology, treatment

Hot flashes (HFs) are a rapid and exaggerated heat dissipation response, consisting of profuse sweating, peripheral vasodilation, and feelings of intense, internal heat. They are triggered by small elevations in core body temperature (Tc) acting within a greatly reduced thermoneutral zone, i.e., the...

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Vydané v:The Journal of steroid biochemistry and molecular biology Ročník 142; s. 115 - 120
Hlavný autor: Freedman, Robert R.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.07.2014
Predmet:
Adult
Body Temperature Regulation - physiology
Circadian Rhythm
Clonidine - therapeutic use
Estrogen Replacement Therapy
Female
Hot flashes
Hot Flashes - physiopathology
Hot Flashes - therapy
Humans
Menopause
Menopause - physiology
Middle Aged
Serotonin Uptake Inhibitors - therapeutic use
Sleep
Sleep - physiology
Sweating
Thermoregulation
Thermoregulation
Sleep
Menopause
Hot flashes
ISSN:0960-0760, 1879-1220, 1879-1220
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Shrnutí:Hot flashes (HFs) are a rapid and exaggerated heat dissipation response, consisting of profuse sweating, peripheral vasodilation, and feelings of intense, internal heat. They are triggered by small elevations in core body temperature (Tc) acting within a greatly reduced thermoneutral zone, i.e., the Tc region between the upper (sweating) and lower (shivering) thresholds. This is due in part, but not entirely, to estrogen depletion at menopause. Elevated central sympathetic activation, mediated through α2-adrenergic receptors, is one factor responsible for narrowing of the thermoneutral zone. Procedures which reduce this activation, such as paced respiration and clonidine administration, ameliorate HFs as will peripheral cooling. HFs are responsible for some, but not all, of the sleep disturbance reported during menopause. Recent work calls into question the role of serotonin in HFs. This article is part of a Special Issue entitled ‘Menopause’.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0960-0760
1879-1220
1879-1220
DOI:10.1016/j.jsbmb.2013.08.010