Phage Therapy: Beyond Antibacterial Action

Until recently, phages were considered as mere "bacteria eaters" with potential for use in combating antimicrobial resistance. The real value of phage therapy assessed according to the standards of evidence-based medicine awaits confirmation by clinical trials. However, the progress in res...

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Published in:Frontiers in medicine Vol. 5; p. 146
Main Authors: Górski, Andrzej, Jończyk-Matysiak, Ewa, Międzybrodzki, Ryszard, Weber-Dąbrowska, Beata, Łusiak-Szelachowska, Marzanna, Bagińska, Natalia, Borysowski, Jan, Łobocka, Małgorzata B., Węgrzyn, Alicja, Węgrzyn, Grzegorz
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 23.05.2018
Subjects:
immunomodulation
inflammation
Medicine
phage
phage therapy
prophage induction
immunomodulation
prophage induction
phage
inflammation
phage therapy
ISSN:2296-858X, 2296-858X
Online Access:Get full text
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Summary:Until recently, phages were considered as mere "bacteria eaters" with potential for use in combating antimicrobial resistance. The real value of phage therapy assessed according to the standards of evidence-based medicine awaits confirmation by clinical trials. However, the progress in research on phage biology has shed more light on the significance of phages. Accumulating data indicate that phages may also interact with eukaryotic cells. How such interactions could be translated into advances in medicine (especially novel means of therapy) is discussed herein.
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Edited by: Ulrich Martin, Hannover Medical School, Germany
Reviewed by: Evgenii Rubalskii, Hannover Medical School, Germany; Hongwei Chen, University of Michigan, United States
This article was submitted to Translational Medicine, a section of the journal Frontiers in Medicine
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2018.00146