Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

Most cancers have lost a critical DNA damage response (DDR) pathway during tumor evolution. These alterations provide a useful explanation for the initial sensitivity of tumors to DNA-targeting chemotherapy. A striking example is dysfunctional homology-directed repair (HDR), e.g., due to inactivatin...

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Veröffentlicht in:	Frontiers in oncology Jg. 10; S. 670
Hauptverfasser:	Liptay, Martin, Barbosa, Joana S., Rottenberg, Sven
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 05.05.2020
Schlagworte:	chemotherapy DNA damage response DNA damage tolerance DNA replication drug resistance Oncology replication fork BRCA1/2 DNA damage tolerance DNA replication DNA damage response PARP inhibitors replication fork drug resistance chemotherapy
ISSN:	2234-943X, 2234-943X
Online-Zugang:	Volltext
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