Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis

Background Post‐operative cognitive dysfunction, a condition distinct from post‐operative delirium (POD), occurs frequently after surgery, and is related to dementia and premature death. Obesity increases the risk of late‐life cognitive impairment, but little is known about its role in post‐operativ...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Diabetes/metabolism research and reviews Ročník 32; číslo 6; s. 643 - 651
Hlavní autoři: Feinkohl, Insa, Winterer, Georg, Pischon, Tobias
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Blackwell Publishing Ltd 01.09.2016
Wiley Subscription Services, Inc
Témata:
adiposity
Body mass index
body weight
Cognitive Dysfunction - etiology
Delirium
Humans
Obesity
Obesity - complications
POCD
post-operative cognitive dysfunction
Postoperative Complications
Prognosis
Surgery
Weight control
body weight
adiposity
post-operative cognitive dysfunction
POCD
obesity
ISSN:1520-7552, 1520-7560
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Background Post‐operative cognitive dysfunction, a condition distinct from post‐operative delirium (POD), occurs frequently after surgery, and is related to dementia and premature death. Obesity increases the risk of late‐life cognitive impairment, but little is known about its role in post‐operative cognitive dysfunction. We conducted a systematic review and meta‐analysis of studies on the association between obesity and risk of post‐operative cognitive dysfunction. Methods PubMed and the Cochrane Library were systematically searched. Studies were included if they had prospective designs, reported on human adults undergoing surgery, if cognitive function was measured pre‐ and post‐surgery, if obesity, body mass index (BMI) and/or body weight were ascertained, and if associations with post‐operative cognitive dysfunction were reported as relative risks or odds ratios. Underweight, weight loss, and post‐operative delirium were not considered. Results Inclusion criteria were met by six articles. Samples totaled 1432 older patients (mean age ≥62 years) who were followed up for 24 h to 12 months after surgery. Analysis of studies with obesity defined as a categorical measure found a non‐significantly higher risk of post‐operative cognitive dysfunction among persons with BMI > 30 kg/m2 versus ≤30 kg/m2 (relative risk 1.27; 95% confidence interval 0.95, 1.70; p = 0.10). No such associations were found for studies that analysed BMI or body weight continuously as predictors of post‐operative cognitive dysfunction (relative risk 0.98 per kg/m2; 95% confidence interval 0.93, 1.03, p = 0.45; relative risk 0.99 per kg; 95% confidence interval 0.89, 1.09; p = 0.83, respectively). Conclusions Few studies have addressed the topic, and the results of these studies provide only limited support for an increased risk of post‐operative cognitive dysfunction in patients who are obese. Further large‐scale, prospective investigations are necessary for clarification. Copyright © 2016 John Wiley & Sons, Ltd.
Bibliografie:ark:/67375/WNG-5293RHW2-Q
istex:BE28150EC3167BC3F3546A711DCA37EA011268F1
European Union - No. F2-2014-602461
ArticleID:DMRR2786
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ObjectType-Review-1
ObjectType-Article-3
ObjectType-Undefined-4
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.2786