Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study

Inflammation is associated with a range of neuropsychiatric symptoms, but the issue of causality remains unclear. We used complementary non-genetic, genetic risk score (GRS), and Mendelian randomization (MR) analyses to examine whether inflammatory markers are associated with affect, depressive and...

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Veröffentlicht in:	Translational psychiatry Jg. 15; H. 1; S. 164 - 14
Hauptverfasser:	Mac Giollabhui, Naoise, Slaney, Chloe, Hemani, Gibran, Foley, Éimear M., van der Most, Peter J., Nolte, Ilja M., Snieder, Harold, Davey Smith, George, Khandaker, Golam M., Hartman, Catharina A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 10.05.2025 Nature Publishing Group
Schlagworte:	13/21 631/208/2489 631/477/2811 Adult Affect Anxiety disorders Anxiety Disorders - blood Anxiety Disorders - genetics Anxiety Disorders - psychology Attention Behavioral Sciences Biological Psychology Biomarkers - blood C-Reactive Protein - metabolism Cognition Cognition & reasoning Cohort analysis Cohort Studies Depressive Disorder - blood Depressive Disorder - genetics Episodic memory Executive Function Female Humans Inflammation Inflammation - blood Inflammation - genetics Inflammation - psychology Interleukin-6 - blood Male Medicine Medicine & Public Health Memory, Episodic Mendelian Randomization Analysis Middle Aged Netherlands Neurosciences Pharmacotherapy Prospective Studies Psychiatry Receptors, Interleukin-6 - blood Receptors, Interleukin-6 - genetics Netherlands
ISSN:	2158-3188, 2158-3188
Online-Zugang:	Volltext
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