Changes of faecal microbiota in patients with Crohn's disease treated with an elemental diet and total parenteral nutrition

Intestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective therapies for Crohn's disease; however, changes of microbiota as a result of both treatments have not been fully elucidated. To elucidate changes of faecal...

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Veröffentlicht in:	Digestive and liver disease Jg. 44; H. 9; S. 736 - 742
Hauptverfasser:	Shiga, Hisashi, Kajiura, Takayuki, Shinozaki, Junko, Takagi, Sho, Kinouchi, Yoshitaka, Takahashi, Seiichi, Negoro, Kenichi, Endo, Katsuya, Kakuta, Yoichi, Suzuki, Manabu, Shimosegawa, Tooru
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.09.2012
Schlagworte:	Adolescent Adult Aged Bacteroides fragilis - genetics Bifidobacterium - genetics Case-Control Studies Clostridium - genetics Crohn Disease - diet therapy Crohn Disease - microbiology Crohn Disease - therapy Crohn's disease DNA, Bacterial - analysis Elemental diet Enterococcus - genetics Feces - microbiology Female Food, Formulated Gastroenterology and Hepatology Humans Intestinal microbiota Male Metagenome - genetics Middle Aged Parenteral Nutrition, Total Polymorphism, Restriction Fragment Length Real-Time Polymerase Chain Reaction T-RFLP Young Adult Crohn's disease Elemental diet Intestinal microbiota T-RFLP
ISSN:	1590-8658, 1878-3562, 1878-3562
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Abstract	Intestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective therapies for Crohn's disease; however, changes of microbiota as a result of both treatments have not been fully elucidated. To elucidate changes of faecal microbiota in Crohn's disease patients treated with elemental diet and total parenteral nutrition. Stool samples were collected from 33 active Crohn's disease patients and 17 healthy subjects, and recollected after elemental diet (8 patients) and total parenteral nutrition (9 patients). Terminal restriction fragment length polymorphism analysis of bacterial 16srDNA was performed to evaluate the whole microbiota. Specific quantitative PCR was then used to determine populations of predominant bacterial groups. In Crohn's disease patients, the number of terminal restriction fragments, which reflects bacterial species, was significantly lower. Populations of total bacteria and Bifidobacterium were significantly lower and the ratio of Enterococcus was higher. The number of terminal restriction fragments was significantly decreased after total parenteral nutrition, but not after elemental diet. Population of Bacteroides fragilis significantly decreased after elemental diet, while population of Enterococcus significantly increased after total parenteral nutrition. Faecal microbiota in Crohn's disease patients was markedly different from healthy subjects. Species diversity was reduced by total parenteral nutrition, but not by elemental diet.
AbstractList	Intestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective therapies for Crohn's disease; however, changes of microbiota as a result of both treatments have not been fully elucidated. To elucidate changes of faecal microbiota in Crohn's disease patients treated with elemental diet and total parenteral nutrition. Stool samples were collected from 33 active Crohn's disease patients and 17 healthy subjects, and recollected after elemental diet (8 patients) and total parenteral nutrition (9 patients). Terminal restriction fragment length polymorphism analysis of bacterial 16srDNA was performed to evaluate the whole microbiota. Specific quantitative PCR was then used to determine populations of predominant bacterial groups. In Crohn's disease patients, the number of terminal restriction fragments, which reflects bacterial species, was significantly lower. Populations of total bacteria and Bifidobacterium were significantly lower and the ratio of Enterococcus was higher. The number of terminal restriction fragments was significantly decreased after total parenteral nutrition, but not after elemental diet. Population of Bacteroides fragilis significantly decreased after elemental diet, while population of Enterococcus significantly increased after total parenteral nutrition. Faecal microbiota in Crohn's disease patients was markedly different from healthy subjects. Species diversity was reduced by total parenteral nutrition, but not by elemental diet. Intestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective therapies for Crohn's disease; however, changes of microbiota as a result of both treatments have not been fully elucidated.BACKGROUNDIntestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective therapies for Crohn's disease; however, changes of microbiota as a result of both treatments have not been fully elucidated.To elucidate changes of faecal microbiota in Crohn's disease patients treated with elemental diet and total parenteral nutrition.AIMTo elucidate changes of faecal microbiota in Crohn's disease patients treated with elemental diet and total parenteral nutrition.Stool samples were collected from 33 active Crohn's disease patients and 17 healthy subjects, and recollected after elemental diet (8 patients) and total parenteral nutrition (9 patients). Terminal restriction fragment length polymorphism analysis of bacterial 16srDNA was performed to evaluate the whole microbiota. Specific quantitative PCR was then used to determine populations of predominant bacterial groups.METHODSStool samples were collected from 33 active Crohn's disease patients and 17 healthy subjects, and recollected after elemental diet (8 patients) and total parenteral nutrition (9 patients). Terminal restriction fragment length polymorphism analysis of bacterial 16srDNA was performed to evaluate the whole microbiota. Specific quantitative PCR was then used to determine populations of predominant bacterial groups.In Crohn's disease patients, the number of terminal restriction fragments, which reflects bacterial species, was significantly lower. Populations of total bacteria and Bifidobacterium were significantly lower and the ratio of Enterococcus was higher. The number of terminal restriction fragments was significantly decreased after total parenteral nutrition, but not after elemental diet. Population of Bacteroides fragilis significantly decreased after elemental diet, while population of Enterococcus significantly increased after total parenteral nutrition.RESULTSIn Crohn's disease patients, the number of terminal restriction fragments, which reflects bacterial species, was significantly lower. Populations of total bacteria and Bifidobacterium were significantly lower and the ratio of Enterococcus was higher. The number of terminal restriction fragments was significantly decreased after total parenteral nutrition, but not after elemental diet. Population of Bacteroides fragilis significantly decreased after elemental diet, while population of Enterococcus significantly increased after total parenteral nutrition.Faecal microbiota in Crohn's disease patients was markedly different from healthy subjects. Species diversity was reduced by total parenteral nutrition, but not by elemental diet.CONCLUSIONFaecal microbiota in Crohn's disease patients was markedly different from healthy subjects. Species diversity was reduced by total parenteral nutrition, but not by elemental diet. Abstract Background Intestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective therapies for Crohn's disease; however, changes of microbiota as a result of both treatments have not been fully elucidated. Aim To elucidate changes of faecal microbiota in Crohn's disease patients treated with elemental diet and total parenteral nutrition. Methods Stool samples were collected from 33 active Crohn's disease patients and 17 healthy subjects, and recollected after elemental diet (8 patients) and total parenteral nutrition (9 patients). Terminal restriction fragment length polymorphism analysis of bacterial 16srDNA was performed to evaluate the whole microbiota. Specific quantitative PCR was then used to determine populations of predominant bacterial groups. Results In Crohn's disease patients, the number of terminal restriction fragments, which reflects bacterial species, was significantly lower. Populations of total bacteria and Bifidobacterium were significantly lower and the ratio of Enterococcus was higher. The number of terminal restriction fragments was significantly decreased after total parenteral nutrition, but not after elemental diet. Population of Bacteroides fragilis significantly decreased after elemental diet, while population of Enterococcus significantly increased after total parenteral nutrition. Conclusion Faecal microbiota in Crohn's disease patients was markedly different from healthy subjects. Species diversity was reduced by total parenteral nutrition, but not by elemental diet.
Author	Kakuta, Yoichi Kajiura, Takayuki Kinouchi, Yoshitaka Negoro, Kenichi Shimosegawa, Tooru Shiga, Hisashi Takagi, Sho Takahashi, Seiichi Shinozaki, Junko Endo, Katsuya Suzuki, Manabu
Author_xml	– sequence: 1 givenname: Hisashi surname: Shiga fullname: Shiga, Hisashi email: shiga@med.tohoku.ac.jp, hshiga@mail.tains.tohoku.ac.jp organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan – sequence: 2 givenname: Takayuki surname: Kajiura fullname: Kajiura, Takayuki organization: Institute for Innovation, Ajinomoto Co., Inc., Kawasaki 210-8681, Japan – sequence: 3 givenname: Junko surname: Shinozaki fullname: Shinozaki, Junko organization: Institute for Innovation, Ajinomoto Co., Inc., Kawasaki 210-8681, Japan – sequence: 4 givenname: Sho surname: Takagi fullname: Takagi, Sho organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan – sequence: 5 givenname: Yoshitaka surname: Kinouchi fullname: Kinouchi, Yoshitaka organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan – sequence: 6 givenname: Seiichi surname: Takahashi fullname: Takahashi, Seiichi organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan – sequence: 7 givenname: Kenichi surname: Negoro fullname: Negoro, Kenichi organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan – sequence: 8 givenname: Katsuya surname: Endo fullname: Endo, Katsuya organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan – sequence: 9 givenname: Yoichi surname: Kakuta fullname: Kakuta, Yoichi organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan – sequence: 10 givenname: Manabu surname: Suzuki fullname: Suzuki, Manabu organization: Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., Kawasaki 210-8681, Japan – sequence: 11 givenname: Tooru surname: Shimosegawa fullname: Shimosegawa, Tooru organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
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Keywords	Crohn's disease Elemental diet Intestinal microbiota T-RFLP
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Snippet	Intestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective therapies for Crohn's... Abstract Background Intestinal microbiota contributes to the pathogenesis of Crohn's disease. Elemental diet and total parenteral nutrition are effective...
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SubjectTerms	Adolescent Adult Aged Bacteroides fragilis - genetics Bifidobacterium - genetics Case-Control Studies Clostridium - genetics Crohn Disease - diet therapy Crohn Disease - microbiology Crohn Disease - therapy Crohn's disease DNA, Bacterial - analysis Elemental diet Enterococcus - genetics Feces - microbiology Female Food, Formulated Gastroenterology and Hepatology Humans Intestinal microbiota Male Metagenome - genetics Middle Aged Parenteral Nutrition, Total Polymorphism, Restriction Fragment Length Real-Time Polymerase Chain Reaction T-RFLP Young Adult
Title	Changes of faecal microbiota in patients with Crohn's disease treated with an elemental diet and total parenteral nutrition
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