Acute viral hepatitis – Should the current screening strategy be modified?

The epidemiology of viral hepatitis has changed. Since the introduction of safe and effective vaccines for hepatitis A and B in 1980s, the incidence of acute infections caused by these viruses has been declining in the UK. At the same time, hepatitis E virus (HEV) has been recognised as an increasin...

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Vydáno v:Journal of clinical virology Ročník 59; číslo 3; s. 184 - 187
Hlavní autoři: Harvala, Heli, Wong, Vincent, Simmonds, Peter, Johannessen, Ingolfur, Ramalingam, Sandeep
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.03.2014
Témata:
Acute Disease
Acute hepatitis
Adult
Alanine Transaminase - blood
Allergy and Immunology
CMV
Cohort Studies
EBV
Female
HAV
Hepatitis E
Hepatitis, Viral, Human - diagnosis
Hepatitis, Viral, Human - epidemiology
Hepatitis, Viral, Human - virology
Humans
Infectious Disease
Male
Middle Aged
United Kingdom - epidemiology
Virology - methods
Virology - statistics & numerical data
Virus
Virus
EBV
Hepatitis E
Acute hepatitis
HAV
CMV
ISSN:1386-6532, 1873-5967, 1873-5967
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Shrnutí:The epidemiology of viral hepatitis has changed. Since the introduction of safe and effective vaccines for hepatitis A and B in 1980s, the incidence of acute infections caused by these viruses has been declining in the UK. At the same time, hepatitis E virus (HEV) has been recognised as an increasingly important cause of acute hepatitis, but testing is not widely available. The aim of this study was to establish the viral causes of acute hepatitis, and use that data to modify the current diagnostic algorithm. A Cognos search was performed to collate subjects tested for HAV, HBV, HCV, HEV, EBV and CMV between June 2010 and December 2012. Information included virological result and their ALT level if done within 5 days from virological testing. From 3462 subjects with suspected acute viral hepatitis, only 25% had biochemical evidence of acute hepatitis (n=854; ALT>100IU/l). The frequency of detection of acute HEV infection (25/409) was over 31-times higher than that of HAV (6/3462), and 7-times higher than that of HBV (24/3462). Most cases of acute HAV, HEV, EBV and CMV infections presented with abnormal ALT levels. Most EBV infections were associated with lymphadenopathy (23/34); in comparison most of CMV infections were not associated with lymphadenopathy (18/22). HEV screening should be included in the initial testing panel for acute hepatitis and screening at least for HAV and HEV might be limited to those with abnormal ALT levels.
Bibliografie:ObjectType-Article-1
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ISSN:1386-6532
1873-5967
1873-5967
DOI:10.1016/j.jcv.2014.01.001