The Hippo Pathway: A Master Regulatory Network Important in Cancer

The Hippo pathway is pervasively activated and has been well recognized to play critical roles in human cancer. The deregulation of Hippo signaling involved in cancer development, progression, and resistance to cancer treatment have been confirmed in several human cancers. Its biological significanc...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Vol. 10; no. 6; p. 1416
Main Authors: Liu, Qiuping, Liu, Xiaomeng, Song, Guanbin
Format: Journal Article
Language:English
Published: Basel MDPI AG 07.06.2021
MDPI
Subjects:
Apoptosis
Breast cancer
Cancer
cancer therapy
Cell growth
Cytoskeleton
Enzymes
Gene expression
Glucose
Hippo pathway
Homeostasis
Insects
Kinases
Liver cancer
metabolic regulation
Metabolism
Metabolites
Metastasis
Proteins
Review
Signal transduction
Stem cells
Tumorigenesis
Tumors
ISSN:2073-4409, 2073-4409
Online Access:Get full text
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Summary:The Hippo pathway is pervasively activated and has been well recognized to play critical roles in human cancer. The deregulation of Hippo signaling involved in cancer development, progression, and resistance to cancer treatment have been confirmed in several human cancers. Its biological significance and deregulation in cancer have drawn increasing interest in the past few years. A fundamental understanding of the complexity of the Hippo pathway in cancer is crucial for improving future clinical interventions and therapy for cancers. In this review, we try to clarify the complex regulation and function of the Hippo signaling network in cancer development, including its role in signal transduction, metabolic regulation, and tumor development, as well as tumor therapies targeting the Hippo pathway.
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ISSN:2073-4409
2073-4409
DOI:10.3390/cells10061416