Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging
Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by phy...
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| Vydáno v: | Frontiers in physiology Ročník 10; s. 312 |
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26.03.2019
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| Abstract | Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20-87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle. |
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| AbstractList | Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20–87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle. Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20-87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle.Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20-87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle. |
| Author | Sen, Ranjan Chia, Chee W. Simonsick, Eleanor M. Gonzalez-Freire, Marta Lyashkov, Alexey Ubaida-Mohien, Ceereena Moaddel, Ruin Ferrucci, Luigi |
| AuthorAffiliation | Intramural Research Program, National Institute on Aging – National Institutes of Health , Baltimore, MD , United States |
| AuthorAffiliation_xml | – name: Intramural Research Program, National Institute on Aging – National Institutes of Health , Baltimore, MD , United States |
| Author_xml | – sequence: 1 givenname: Ceereena surname: Ubaida-Mohien fullname: Ubaida-Mohien, Ceereena – sequence: 2 givenname: Marta surname: Gonzalez-Freire fullname: Gonzalez-Freire, Marta – sequence: 3 givenname: Alexey surname: Lyashkov fullname: Lyashkov, Alexey – sequence: 4 givenname: Ruin surname: Moaddel fullname: Moaddel, Ruin – sequence: 5 givenname: Chee W. surname: Chia fullname: Chia, Chee W. – sequence: 6 givenname: Eleanor M. surname: Simonsick fullname: Simonsick, Eleanor M. – sequence: 7 givenname: Ranjan surname: Sen fullname: Sen, Ranjan – sequence: 8 givenname: Luigi surname: Ferrucci fullname: Ferrucci, Luigi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30971946$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/j.1749-6632.2010.05748.x 10.1007/s00520-017-3883-5 10.1111/j.1600-0838.2010.01136.x 10.1186/s13059-017-1344-6 10.1016/j.euprot.2015.02.002 10.1002/jcp.25477 10.1021/ac0341261 10.1002/jcsm.12121 10.1080/02640410410001675342 10.1038/s41598-018-28540-5 10.1097/NEN.0000000000000032 10.1152/physiolgenomics.00003.2008 10.1016/j.neuron.2018.02.027 10.1101/cshperspect.a029686 10.1093/gerona/57.10.B359 10.1093/gerona/glr055 10.1038/nature10758 10.1113/jphysiol.2008.153916 10.1016/j.arr.2017.04.004 10.1016/j.tma.2017.09.005 10.1021/ac025747h 10.1016/j.redox.2015.05.006 10.1016/j.celrep.2017.05.054 10.1016/j.freeradbiomed.2007.02.001 10.1242/dev.085969 10.1016/j.bbrc.2012.01.018 10.1016/j.humimm.2018.11.001 10.3389/fphys.2017.00713 10.1111/acel.12750 10.1080/09291016.2017.1323422 10.1016/j.cmet.2017.02.009 10.1111/acel.12433 10.1111/apha.12898 10.2337/db08-0349 10.1055/s-0043-119882 10.3233/JAD-170659 10.1097/00005768-200009000-00012 10.1038/nbt.1621 10.1002/pmic.200800365 10.1046/j.1365-2990.1998.00149.x 10.1111/j.1440-1681.2006.04470.x 10.1016/j.cmet.2015.05.011 10.1016/j.cmet.2016.05.007 10.1016/j.cmet.2012.12.012 10.1093/gerona/glv231 10.1093/gerona/glw059 10.1097/00005768-200103000-00010 10.32607/20758251-2014-6-3-66-75 10.1073/pnas.1322118111 10.1152/ajpregu.00677.2006 10.1093/nar/gkq614 10.1093/nar/gkv1145 10.1002/cm.21188 10.1016/j.bbamcr.2007.10.001 10.1139/y59-099 10.1007/s00109-013-1096-z 10.1021/pr300624g 10.1186/1471-2105-11-367 10.1093/gerona/gls237 10.1038/nrm3742 10.1161/ATVBAHA.107.153288 10.1371/journal.pmed.0050051 10.1111/acel.12499 10.1016/j.tem.2013.12.001 10.1111/acel.12646 10.1111/j.1532-5415.2004.52154.x 10.1371/journal.pone.0149082 10.3389/fphys.2012.00142 10.1074/jbc.M312659200 10.1152/ajpregu.00847.2007 10.1089/ars.2017.7264 10.1038/s41569-018-0064-2 10.4161/auto.7.12.17877 10.1002/ajhb.23102 10.1152/ajpendo.00508.2001 10.3389/fimmu.2018.02187 10.1093/gerona/gly072 10.1126/science.283.5407.1488 10.1016/j.cell.2017.05.015 10.3389/fphys.2016.00486 10.1038/s41598-018-21585-6 10.1007/s40279-016-0566-1 10.1210/jcem.86.12.8075 10.1186/1471-2164-15-1165 10.1007/s004240100628 10.1016/j.tem.2015.02.009 10.1096/fj.04-3149fje 10.1111/febs.14417 10.1007/s10495-006-0197-3 10.1096/fj.201700531R 10.2337/db07-0255 10.1111/jgs.12740 10.1155/2018/2894247 10.1016/0021-9681(78)90058-9 10.2147/CIA.S44112 10.1111/acel.12568 10.1152/japplphysiol.00622.2016 10.1371/journal.pone.0000465 10.1179/135100008X308894 10.1002/pmic.201000722 10.1038/nrm.2016.93 10.1074/mcp.M700304-MCP200 10.1111/jgs.12653 10.3389/fphys.2018.00203 10.1074/jbc.272.43.27484 10.1053/j.jrn.2004.09.009 10.1016/j.exger.2018.10.011 10.1016/j.jprot.2015.03.028 |
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| Copyright | Copyright © 2019 Ubaida-Mohien, Gonzalez-Freire, Lyashkov, Moaddel, Chia, Simonsick, Sen and Ferrucci. 2019 Ubaida-Mohien, Gonzalez-Freire, Lyashkov, Moaddel, Chia, Simonsick, Sen and Ferrucci |
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| Keywords | proteomics DNA damage mitochondria mass spectrometry immunity spliceosome skeletal muscle physical activity |
| Language | English |
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| References | He (B38) 2017; 169 Kazemi (B49) 2016; 5 Duggal (B23) 2018; 17 Syed (B100) 2006; 11 Windsor (B110) 2018; 9 Abe (B1) 2018; 30 Saudemont (B96) 2017; 18 Li (B60) 2017; 1 Grumati (B32) 2011; 7 Phaneuf (B87) 2001; 33 Taylor (B101) 1978; 31 Gonzalez-Freire (B29) 2017; 8 Vezzoli (B105) 2010; 1209 de Castro (B19) 2018 Iqbal (B45) 2014; 71 Doran (B22) 2009; 9 Munoz (B74) 2018; 73 Wilkinson (B109) 2008; 586 Hojlund (B42) 2008; 7 Herbrich (B39) 2013; 12 Bonkowski (B10) 2016; 17 Goodpaster (B30) 2001; 86 Peake (B83) 2017; 122 Sallis (B94) 2000; 32 Bligh (B8) 1959; 37 Paterson (B81) 2007 Bengtsson (B5) 2001; 443 Moore (B71) 2014; 62 Wang (B108) 2013; 140 Kohn (B53) 2011; 21 Nicolas (B79) 2018; 97 Gomez-Cabrera (B28) 2008; 44 Deschenes (B21) 2017; 16 Choi (B17) 2016; 71 Margaritelis (B66) 2018; 222 Matera (B67) 2014; 15 Biolo (B6) 2005; 15 (B90) 2016 Murgia (B75) 2017; 19 Huttemann (B44) 2007; 1773 Argyropoulos (B3) 2009; 36 He (B37) 2016; 7 Bland (B7) 2010; 38 Egan (B24) 2013; 17 Nakamura (B76) 2012; 418 Mahoney (B65) 2008; 294 Lu (B63) 2018; 61 Alturki (B2) 2018; 114 Bogdanis (B9) 2012; 3 Brach (B12) 2004; 52 Hicks (B40) 2012; 67 Cartee (B15) 2016; 23 Saraste (B95) 1999; 283 Paulsen (B82) 2007; 293 Trapnell (B102) 2010; 28 Robinson (B91) 2017; 25 Gueugneau (B34) 2014; 15 Petriz (B86) 2017; 232 Wang (B107) 2011; 11 Schild (B97) 2015; 122 Lee (B59) 2016; 15 Metter (B69) 2002; 57 Kazior (B50) 2016; 11 He (B36) 2012; 481 Lanningham-Foster (B54) 2002; 282 Milanovic (B70) 2013; 8 Hou (B43) 2017; 48 Chang (B16) 2014; 25 Podhorska-Okolow (B89) 1998; 24 Vizcaino (B106) 2016; 44 Flowers (B26) 2018; 26 Perandini (B84) 2018; 285 Kammers (B48) 2015; 7 Sellami (B99) 2018; 9 Schrack (B98) 2014; 62 Neufer (B78) 2015; 22 Rodriguez (B93) 2016; 15 Larina (B56) 2014; 6 Palmnas (B80) 2018; 8 Bouzid (B11) 2018; 39 Jaworska (B47) 2014; 111 Mahoney (B64) 2005; 19 Crane (B18) 2013; 68 Izquierdo (B46) 2004; 22 Keller (B51) 2002; 74 Lourenco dos Santos (B62) 2015; 5 Gaujoux (B27) 2010; 11 Kleinert (B52) 2018; 8 Bringman-Rodenbarger (B13) 2018; 28 Hitomi (B41) 2008; 13 Latorre (B57) 2017; 36 Hamburg (B35) 2007; 27 Pietilainen (B88) 2008; 5 Guelfi (B33) 2006; 33 Le Bras (B58) 2004; 279 de Sousa (B20) 2017; 47 Ferrucci (B25) 2018; 15 Trappe (B103) 2016; 71 Zane (B111) 2017; 16 Louis (B61) 1997; 272 Groennebaek (B31) 2017; 8 Mosole (B72) 2014; 73 Perry (B85) 2018; 8 Vainshtein (B104) 2014; 92 Mounier (B73) 2015; 26 Nesvizhskii (B77) 2003; 75 Rockl (B92) 2007; 56 Camera (B14) 2017; 31 Melov (B68) 2007; 2 Lanza (B55) 2008; 57 Belaya (B4) 2018; 2018 |
| References_xml | – volume: 1209 start-page: 83 year: 2010 ident: B105 article-title: Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle. publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2010.05748.x – volume: 26 start-page: 739 year: 2018 ident: B26 article-title: Differential expression of genes and differentially perturbed pathways associated with very high evening fatigue in oncology patients receiving chemotherapy. publication-title: Support. Care Cancer doi: 10.1007/s00520-017-3883-5 – volume: 21 start-page: 765 year: 2011 ident: B53 article-title: Specific muscle adaptations in type II fibers after high-intensity interval training of well-trained runners. publication-title: Scand. J. Med. Sci. Sports doi: 10.1111/j.1600-0838.2010.01136.x – volume: 18 year: 2017 ident: B96 article-title: The fitness cost of mis-splicing is the main determinant of alternative splicing patterns. publication-title: Genome Biol. doi: 10.1186/s13059-017-1344-6 – volume: 7 start-page: 11 year: 2015 ident: B48 article-title: Detecting significant changes in protein abundance. publication-title: EuPA Open Proteom. doi: 10.1016/j.euprot.2015.02.002 – volume: 232 start-page: 257 year: 2017 ident: B86 article-title: The effects of acute and chronic exercise on skeletal muscle proteome. publication-title: J. Cell. Physiol. doi: 10.1002/jcp.25477 – volume: 75 start-page: 4646 year: 2003 ident: B77 article-title: A statistical model for identifying proteins by tandem mass spectrometry. publication-title: Anal. Chem. doi: 10.1021/ac0341261 – volume: 8 start-page: 5 year: 2017 ident: B29 article-title: The human skeletal muscle proteome project: a reappraisal of the current literature. publication-title: J. Cachexia Sarcopenia Muscle doi: 10.1002/jcsm.12121 – volume: 22 start-page: 465 year: 2004 ident: B46 article-title: Maximal strength and power, muscle mass, endurance and serum hormones in weightlifters and road cyclists. publication-title: J. Sports Sci. doi: 10.1080/02640410410001675342 – volume: 8 year: 2018 ident: B52 article-title: Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training. publication-title: Sci. Rep. doi: 10.1038/s41598-018-28540-5 – volume: 73 start-page: 284 year: 2014 ident: B72 article-title: Long-term high-level exercise promotes muscle reinnervation with age. publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1097/NEN.0000000000000032 – volume: 36 start-page: 79 year: 2009 ident: B3 article-title: KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. publication-title: Physiol. Genomics doi: 10.1152/physiolgenomics.00003.2008 – volume: 97 start-page: 1268 year: 2018 ident: B79 article-title: Genome-wide analyses identify KIF5A as a novel ALS gene. publication-title: Neuron doi: 10.1016/j.neuron.2018.02.027 – volume: 8 year: 2018 ident: B85 article-title: Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: historical advances, current knowledge, and future challenges. publication-title: Cold Spring Harb. Perspect. Med. doi: 10.1101/cshperspect.a029686 – volume: 57 start-page: B359 year: 2002 ident: B69 article-title: Skeletal muscle strength as a predictor of all-cause mortality in healthy men. publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/57.10.B359 – volume: 67 start-page: 66 year: 2012 ident: B40 article-title: Absolute strength and loss of strength as predictors of mobility decline in older adults: the InCHIANTI study. publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glr055 – volume: 481 start-page: 511 year: 2012 ident: B36 article-title: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. publication-title: Nature doi: 10.1038/nature10758 – volume: 586 start-page: 3701 year: 2008 ident: B109 article-title: Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. publication-title: J. Physiol. doi: 10.1113/jphysiol.2008.153916 – volume: 36 start-page: 165 year: 2017 ident: B57 article-title: Splicing regulatory factors, ageing and age-related disease. publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2017.04.004 – volume: 5 start-page: 34 year: 2016 ident: B49 article-title: Effects detraining on KIF5B gene expression in sciatic nerve fiber of male Wistar rats. publication-title: JNASCI – volume: 1 start-page: 32 year: 2017 ident: B60 article-title: Alternative splicing in aging and age-related diseases. publication-title: Transl. Med. Aging doi: 10.1016/j.tma.2017.09.005 – volume: 74 start-page: 5383 year: 2002 ident: B51 article-title: Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. publication-title: Anal. Chem. doi: 10.1021/ac025747h – volume: 5 start-page: 267 year: 2015 ident: B62 article-title: Oxidative proteome alterations during skeletal muscle ageing. publication-title: Redox Biol. doi: 10.1016/j.redox.2015.05.006 – volume: 19 start-page: 2396 year: 2017 ident: B75 article-title: Single muscle fiber proteomics reveals fiber-type-specific features of human muscle aging. publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.05.054 – volume: 44 start-page: 126 year: 2008 ident: B28 article-title: Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2007.02.001 – volume: 140 start-page: 617 year: 2013 ident: B108 article-title: Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions. publication-title: Development doi: 10.1242/dev.085969 – volume: 418 start-page: 313 year: 2012 ident: B76 article-title: Identification of blood biomarkers of aging by transcript profiling of whole blood. publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2012.01.018 – year: 2018 ident: B19 article-title: Intracellular antigen processing by ERAP2: molecular mechanism and roles in health and disease. publication-title: Hum. Immunol. doi: 10.1016/j.humimm.2018.11.001 – volume: 8 year: 2017 ident: B31 article-title: Impact of resistance training on skeletal muscle mitochondrial biogenesis, content, and function. publication-title: Front. Physiol. doi: 10.3389/fphys.2017.00713 – volume: 17 year: 2018 ident: B23 article-title: Major features of immunosenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. publication-title: Aging Cell doi: 10.1111/acel.12750 – volume: 48 start-page: 939 year: 2017 ident: B43 article-title: Clock gene affect the noncanonical NF-κB pathway via circadian variation of Otud7b. publication-title: Biol. Rhythm Res. doi: 10.1080/09291016.2017.1323422 – volume: 25 start-page: 581 year: 2017 ident: B91 article-title: Enhanced protein translation underlies improved metabolic and physical adaptations to different exercise training modes in young and old humans. publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.02.009 – volume: 15 start-page: 267 year: 2016 ident: B93 article-title: Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging. publication-title: Aging Cell doi: 10.1111/acel.12433 – volume: 222 year: 2018 ident: B66 article-title: Adaptations to endurance training depend on exercise-induced oxidative stress: exploiting redox interindividual variability. publication-title: Acta Physiol. doi: 10.1111/apha.12898 – volume: 57 start-page: 2933 year: 2008 ident: B55 article-title: Endurance exercise as a countermeasure for aging. publication-title: Diabetes Metab. Res. Rev. doi: 10.2337/db08-0349 – volume: 39 start-page: 21 year: 2018 ident: B11 article-title: Lifelong voluntary exercise modulates age-related changes in oxidative stress. publication-title: Int. J. Sports Med. doi: 10.1055/s-0043-119882 – volume: 61 start-page: 1311 year: 2018 ident: B63 article-title: Dysregulation and dislocation of SFPQ disturbed DNA organization in Alzheimer’s disease and frontotemporal dementia. publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-170659 – volume: 32 start-page: 1598 year: 2000 ident: B94 article-title: Age-related decline in physical activity: a synthesis of human and animal studies. publication-title: Med. Sci. Sports Exerc. doi: 10.1097/00005768-200009000-00012 – volume: 28 start-page: 511 year: 2010 ident: B102 article-title: Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1621 – volume: 9 start-page: 989 year: 2009 ident: B22 article-title: Proteomics of skeletal muscle aging. publication-title: Proteomics doi: 10.1002/pmic.200800365 – volume: 24 start-page: 518 year: 1998 ident: B89 article-title: Apoptosis of myofibres and satellite cells: exercise-induced damage in skeletal muscle of the mouse. publication-title: Neuropathol. Appl. Neurobiol. doi: 10.1046/j.1365-2990.1998.00149.x – volume: 33 start-page: 952 year: 2006 ident: B33 article-title: A proteomic analysis of the acute effects of high-intensity exercise on skeletal muscle proteins in fasted rats. publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/j.1440-1681.2006.04470.x – volume: 22 start-page: 4 year: 2015 ident: B78 article-title: Understanding the cellular and molecular mechanisms of physical activity-induced health benefits. publication-title: Cell Metab. doi: 10.1016/j.cmet.2015.05.011 – volume: 23 start-page: 1034 year: 2016 ident: B15 article-title: Exercise promotes healthy aging of skeletal muscle. publication-title: Cell Metab. doi: 10.1016/j.cmet.2016.05.007 – volume: 17 start-page: 162 year: 2013 ident: B24 article-title: Exercise metabolism and the molecular regulation of skeletal muscle adaptation. publication-title: Cell Metab. doi: 10.1016/j.cmet.2012.12.012 – volume: 71 start-page: 1289 year: 2016 ident: B103 article-title: COX inhibitor influence on skeletal muscle fiber size and metabolic adaptations to resistance exercise in older adults. publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glv231 – volume: 71 start-page: 1638 year: 2016 ident: B17 article-title: 31P magnetic resonance spectroscopy assessment of muscle bioenergetics as a predictor of gait speed in the Baltimore Longitudinal Study of Aging. publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glw059 – volume: 33 start-page: 393 year: 2001 ident: B87 article-title: Apoptosis and exercise. publication-title: Med. Sci. Sports Exerc. doi: 10.1097/00005768-200103000-00010 – volume: 6 start-page: 66 year: 2014 ident: B56 article-title: The proteome of a healthy guman during physical activity under extreme conditions. publication-title: Acta Naturae doi: 10.32607/20758251-2014-6-3-66-75 – volume: 111 start-page: E2110 year: 2014 ident: B47 article-title: NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1322118111 – volume: 293 start-page: R844 year: 2007 ident: B82 article-title: Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans. publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00677.2006 – volume: 38 start-page: 7651 year: 2010 ident: B7 article-title: Global regulation of alternative splicing during myogenic differentiation. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq614 – volume: 44 start-page: D447 year: 2016 ident: B106 article-title: 2016 update of the PRIDE database and its related tools. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1145 – volume: 71 start-page: 564 year: 2014 ident: B45 article-title: Cytoskeletal regulation of mitochondrial movements in myoblasts. publication-title: Cytoskeleton doi: 10.1002/cm.21188 – volume: 1773 start-page: 1701 year: 2007 ident: B44 article-title: Regulation of mitochondrial oxidative phosphorylation through cell signaling. publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2007.10.001 – volume: 37 start-page: 911 year: 1959 ident: B8 article-title: A rapid method of total lipid extraction and purification. publication-title: Can. J. Biochem. Physiol. doi: 10.1139/y59-099 – volume: 92 start-page: 127 year: 2014 ident: B104 article-title: Skeletal muscle, autophagy, and physical activity: the menage a trois of metabolic regulation in health and disease. publication-title: J. Mol. Med. doi: 10.1007/s00109-013-1096-z – volume: 12 start-page: 594 year: 2013 ident: B39 article-title: Statistical inference from multiple iTRAQ experiments without using common reference standards. publication-title: J. Proteome Res. doi: 10.1021/pr300624g – volume: 11 year: 2010 ident: B27 article-title: A flexible R package for nonnegative matrix factorization. publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-11-367 – volume: 68 start-page: 631 year: 2013 ident: B18 article-title: Long-term aerobic exercise is associated with greater muscle strength throughout the life span. publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/gls237 – volume: 15 start-page: 108 year: 2014 ident: B67 article-title: A day in the life of the spliceosome. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3742 – volume: 27 start-page: 2650 year: 2007 ident: B35 article-title: Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.107.153288 – volume: 5 year: 2008 ident: B88 article-title: Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. publication-title: PLoS Med. doi: 10.1371/journal.pmed.0050051 – volume: 15 start-page: 903 year: 2016 ident: B59 article-title: Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. publication-title: Aging Cell doi: 10.1111/acel.12499 – volume: 25 start-page: 138 year: 2014 ident: B16 article-title: SIRT1 and other sirtuins in metabolism. publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2013.12.001 – volume: 16 start-page: 918 year: 2017 ident: B21 article-title: The emerging role of alternative splicing in senescence and aging. publication-title: Aging Cell doi: 10.1111/acel.12646 – volume: 52 start-page: 502 year: 2004 ident: B12 article-title: The association between physical function and lifestyle activity and exercise in the health, aging and body composition study. publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.2004.52154.x – volume: 11 year: 2016 ident: B50 article-title: Endurance exercise enhances the effect of strength training on muscle fiber size and protein expression of Akt and mTOR. publication-title: PLoS One doi: 10.1371/journal.pone.0149082 – volume: 3 year: 2012 ident: B9 article-title: Effects of physical activity and inactivity on muscle fatigue. publication-title: Front. Physiol. doi: 10.3389/fphys.2012.00142 – volume: 279 start-page: 15550 year: 2004 ident: B58 article-title: Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. publication-title: J. Biol. Chem. doi: 10.1074/jbc.M312659200 – volume: 294 start-page: R1901 year: 2008 ident: B65 article-title: Gene expression profiling in human skeletal muscle during recovery from eccentric exercise. publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00847.2007 – volume: 28 start-page: 677 year: 2018 ident: B13 article-title: Emerging roles for SIRT5 in metabolism and cancer. publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2017.7264 – volume: 15 start-page: 505 year: 2018 ident: B25 article-title: Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. publication-title: Nat. Rev. Cardiol. doi: 10.1038/s41569-018-0064-2 – volume: 7 start-page: 1415 year: 2011 ident: B32 article-title: Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles. publication-title: Autophagy doi: 10.4161/auto.7.12.17877 – volume: 30 year: 2018 ident: B1 article-title: Skeletal muscle mass in human athletes: what is the upper limit? publication-title: Am. J. Hum. Biol. doi: 10.1002/ajhb.23102 – volume: 282 start-page: E1197 year: 2002 ident: B54 article-title: Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response. publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00508.2001 – volume: 9 year: 2018 ident: B99 article-title: Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging? publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.02187 – volume: 73 start-page: 1594 year: 2018 ident: B74 article-title: Physical exercise improves aging-related changes in angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia nigra. publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/gly072 – volume: 283 start-page: 1488 year: 1999 ident: B95 article-title: Oxidative phosphorylation at the fin de siecle. publication-title: Science doi: 10.1126/science.283.5407.1488 – volume: 169 start-page: 1000 year: 2017 ident: B38 article-title: Senescence in health and disease. publication-title: Cell doi: 10.1016/j.cell.2017.05.015 – volume: 7 year: 2016 ident: B37 article-title: Redox mechanism of reactive oxygen species in exercise. publication-title: Front. Physiol. doi: 10.3389/fphys.2016.00486 – volume: 8 year: 2018 ident: B80 article-title: Serum metabolomics of activity energy expenditure and its relation to metabolic syndrome and obesity. publication-title: Sci. Rep. doi: 10.1038/s41598-018-21585-6 – volume: 47 start-page: 277 year: 2017 ident: B20 article-title: The antioxidant effect of exercise: a systematic review and meta-analysis. publication-title: Sports Med. doi: 10.1007/s40279-016-0566-1 – volume: 86 start-page: 5755 year: 2001 ident: B30 article-title: Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem.86.12.8075 – volume: 15 year: 2014 ident: B34 article-title: Proteomics of muscle chronological ageing in post-menopausal women. publication-title: BMC Genomics doi: 10.1186/1471-2164-15-1165 – volume: 443 start-page: 61 year: 2001 ident: B5 article-title: Mitochondrial transcription factor A and respiratory complex IV increase in response to exercise training in humans. publication-title: Pflugers Arch. doi: 10.1007/s004240100628 – volume: 26 start-page: 275 year: 2015 ident: B73 article-title: Expanding roles for AMPK in skeletal muscle plasticity. publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2015.02.009 – volume: 19 start-page: 1498 year: 2005 ident: B64 article-title: Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. publication-title: FASEB J. doi: 10.1096/fj.04-3149fje – volume: 285 start-page: 1973 year: 2018 ident: B84 article-title: Chronic inflammation in skeletal muscle impairs satellite cells function during regeneration: can physical exercise restore the satellite cell niche? publication-title: FEBS J. doi: 10.1111/febs.14417 – start-page: S69 year: 2007 ident: B81 article-title: Ageing and physical activity: evidence to develop exercise recommendations for older adults. publication-title: Can. J. Public Health – volume: 11 start-page: 2147 year: 2006 ident: B100 article-title: Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation. publication-title: Apoptosis doi: 10.1007/s10495-006-0197-3 – volume: 31 start-page: 5478 year: 2017 ident: B14 article-title: Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. publication-title: FASEB J. doi: 10.1096/fj.201700531R – volume: 56 start-page: 2062 year: 2007 ident: B92 article-title: Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift. publication-title: Diabetes Metab. Res. Rev. doi: 10.2337/db07-0255 – volume: 62 start-page: 667 year: 2014 ident: B98 article-title: ”IDEAL” aging is associated with lower resting metabolic rate: the Baltimore Longitudinal Study of Aging. publication-title: J. Am. Geriatr. Soc. doi: 10.1111/jgs.12740 – volume: 2018 year: 2018 ident: B4 article-title: Long-term exercise protects against cellular stresses in aged mice. publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2018/2894247 – volume: 31 start-page: 741 year: 1978 ident: B101 article-title: A questionnaire for the assessment of leisure time physical activities. publication-title: J. Chronic Dis. doi: 10.1016/0021-9681(78)90058-9 – volume: 8 start-page: 549 year: 2013 ident: B70 article-title: Age-related decrease in physical activity and functional fitness among elderly men and women. publication-title: Clin. Interv. Aging doi: 10.2147/CIA.S44112 – volume: 16 start-page: 461 year: 2017 ident: B111 article-title: Muscle strength mediates the relationship between mitochondrial energetics and walking performance. publication-title: Aging Cell doi: 10.1111/acel.12568 – volume: 122 start-page: 1077 year: 2017 ident: B83 article-title: Recovery of the immune system after exercise. publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00622.2016 – volume: 2 year: 2007 ident: B68 article-title: Resistance exercise reverses aging in human skeletal muscle. publication-title: PLoS One doi: 10.1371/journal.pone.0000465 – volume: 13 start-page: 213 year: 2008 ident: B41 article-title: Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta. publication-title: Redox Rep. doi: 10.1179/135100008X308894 – volume: 11 start-page: 2019 year: 2011 ident: B107 article-title: Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. publication-title: Proteomics doi: 10.1002/pmic.201000722 – volume: 17 start-page: 679 year: 2016 ident: B10 article-title: Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2016.93 – volume: 7 start-page: 257 year: 2008 ident: B42 article-title: Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M700304-MCP200 – volume: 62 start-page: 230 year: 2014 ident: B71 article-title: Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging. publication-title: J. Am. Geriatr. Soc. doi: 10.1111/jgs.12653 – volume: 9 year: 2018 ident: B110 article-title: Cytokine responses to acute exercise in healthy older adults: the effect of cardiorespiratory fitness. publication-title: Front. Physiol. doi: 10.3389/fphys.2018.00203 – volume: 272 start-page: 27484 year: 1997 ident: B61 article-title: Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression. publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.43.27484 – volume: 15 start-page: 49 year: 2005 ident: B6 article-title: Metabolic consequences of physical inactivity. publication-title: J. Ren. Nutr. doi: 10.1053/j.jrn.2004.09.009 – volume: 114 start-page: 33 year: 2018 ident: B2 article-title: Impact of drugs with anti-inflammatory effects on skeletal muscle and inflammation: a systematic literature review. publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2018.10.011 – year: 2016 ident: B90 publication-title: R: A Language and Environment for Statistical Computing. – volume: 122 start-page: 119 year: 2015 ident: B97 article-title: Basal and exercise induced label-free quantitative protein profiling of m. Vastus lateralis in trained and untrained individuals. publication-title: J. Proteomics doi: 10.1016/j.jprot.2015.03.028 |
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