Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging

Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by phy...

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Published in:Frontiers in physiology Vol. 10; p. 312
Main Authors: Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Lyashkov, Alexey, Moaddel, Ruin, Chia, Chee W., Simonsick, Eleanor M., Sen, Ranjan, Ferrucci, Luigi
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 26.03.2019
Subjects:
immunity
mitochondria
physical activity
Physiology
proteomics
skeletal muscle
spliceosome
proteomics
DNA damage
mitochondria
mass spectrometry
immunity
spliceosome
skeletal muscle
physical activity
ISSN:1664-042X, 1664-042X
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Abstract Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20-87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle.
AbstractList Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20-87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle.Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20-87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle.
Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20–87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active). Over 4,000 proteins were quantified, and higher self-reported physical activity was associated with substantial overrepresentation of proteins associated with mitochondria, TCA cycle, structural and contractile muscle, and genome maintenance. Conversely, proteins related to the spliceosome, transcription regulation, immune function, and apoptosis, DNA damage, and senescence were underrepresented with higher self-reported activity. These differences in observed protein expression were related to different levels of physical activity in daily life and not intense competitive exercise. In most instances, differences in protein levels were directly opposite to those reported in the literature observed with aging. These data suggest that being physically active in daily life has strong and biologically detectable beneficial effects on muscle.
Author Sen, Ranjan
Chia, Chee W.
Simonsick, Eleanor M.
Gonzalez-Freire, Marta
Lyashkov, Alexey
Ubaida-Mohien, Ceereena
Moaddel, Ruin
Ferrucci, Luigi
AuthorAffiliation Intramural Research Program, National Institute on Aging – National Institutes of Health , Baltimore, MD , United States
AuthorAffiliation_xml – name: Intramural Research Program, National Institute on Aging – National Institutes of Health , Baltimore, MD , United States
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  surname: Gonzalez-Freire
  fullname: Gonzalez-Freire, Marta
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  givenname: Alexey
  surname: Lyashkov
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Copyright Copyright © 2019 Ubaida-Mohien, Gonzalez-Freire, Lyashkov, Moaddel, Chia, Simonsick, Sen and Ferrucci. 2019 Ubaida-Mohien, Gonzalez-Freire, Lyashkov, Moaddel, Chia, Simonsick, Sen and Ferrucci
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Keywords proteomics
DNA damage
mitochondria
mass spectrometry
immunity
spliceosome
skeletal muscle
physical activity
Language English
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Edited by: Martin Burtscher, University of Innsbruck, Austria
This article was submitted to Exercise Physiology, a section of the journal Frontiers in Physiology
Reviewed by: Esther Dupont-Versteegden, University of Kentucky, United States; Ted G. Graber, The University of Texas Medical Branch at Galveston, United States
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Snippet Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately...
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StartPage 312
SubjectTerms immunity
mitochondria
physical activity
Physiology
proteomics
skeletal muscle
spliceosome
Title Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging
URI https://www.ncbi.nlm.nih.gov/pubmed/30971946
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