Regression of Post-orthodontic Lesions by a Remineralizing Cream

Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cre...

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Vydané v:	Journal of dental research Ročník 88; číslo 12; s. 1148 - 1153
Hlavní autori:	Bailey, D.L., Adams, G.G., Tsao, C.E., Hyslop, A., Escobar, K., Manton, D. J., Reynolds, E.C., Morgan, M.V.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States SAGE Publications 01.12.2009 SAGE PUBLICATIONS, INC
Predmet:	Adolescent Cariostatic Agents - administration & dosage Cariostatic Agents - therapeutic use Caseins - therapeutic use Child clinical trial CPP-ACP Dental Caries - prevention & control Disease Progression Double-Blind Method Female Follow-Up Studies Humans Male Mouthwashes - therapeutic use Orthodontic Brackets - adverse effects Placebos post-orthodontic remineralization Sodium Fluoride - administration & dosage Sodium Fluoride - therapeutic use Tooth Remineralization - methods Toothpastes - therapeutic use Treatment Outcome white-spot lesion remineralization clinical trial white-spot lesion CPP-ACP CPP-ACP, calcium phosphopeptide-amorphous calcium phosphate post-orthodontic ICDAS, International Caries Detection and Assessment System
ISSN:	0022-0345, 1544-0591, 1544-0591
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Abstract	Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide- amorphous calcium phosphate compared with a placebo. Forty-five participants (aged 12–18 yrs) with 408 white-spot lesions were recruited, with 23 participants randomized to the remineralizing cream and 22 to the placebo. Product was applied twice daily after fluoride toothpaste use for 12 weeks. Clinical assessments were performed according to ICDAS II criteria. Transitions between examinations were coded as progressing, regressing, or stable. Ninety-two percent of lesions were assessed as code 2 or 3. For these lesions, 31% more had regressed with the remineralizing cream than with the placebo (OR = 2.3, P = 0.04) at 12 weeks. Significantly more post-orthodontic white-spot lesions regressed with the remineralizing cream compared with a placebo over 12 weeks.
AbstractList	Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide- amorphous calcium phosphate compared with a placebo. Forty-five participants (aged 12-18 yrs) with 408 white-spot lesions were recruited, with 23 participants randomized to the remineralizing cream and 22 to the placebo. Product was applied twice daily after fluoride toothpaste use for 12 weeks. Clinical assessments were performed according to ICDAS II criteria. Transitions between examinations were coded as progressing, regressing, or stable. Ninety-two percent of lesions were assessed as code 2 or 3. For these lesions, 31% more had regressed with the remineralizing cream than with the placebo (OR = 2.3, P = 0.04) at 12 weeks. Significantly more post-orthodontic white-spot lesions regressed with the remineralizing cream compared with a placebo over 12 weeks.Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide- amorphous calcium phosphate compared with a placebo. Forty-five participants (aged 12-18 yrs) with 408 white-spot lesions were recruited, with 23 participants randomized to the remineralizing cream and 22 to the placebo. Product was applied twice daily after fluoride toothpaste use for 12 weeks. Clinical assessments were performed according to ICDAS II criteria. Transitions between examinations were coded as progressing, regressing, or stable. Ninety-two percent of lesions were assessed as code 2 or 3. For these lesions, 31% more had regressed with the remineralizing cream than with the placebo (OR = 2.3, P = 0.04) at 12 weeks. Significantly more post-orthodontic white-spot lesions regressed with the remineralizing cream compared with a placebo over 12 weeks. Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide- amorphous calcium phosphate compared with a placebo. Forty-five participants (aged 12–18 yrs) with 408 white-spot lesions were recruited, with 23 participants randomized to the remineralizing cream and 22 to the placebo. Product was applied twice daily after fluoride toothpaste use for 12 weeks. Clinical assessments were performed according to ICDAS II criteria. Transitions between examinations were coded as progressing, regressing, or stable. Ninety-two percent of lesions were assessed as code 2 or 3. For these lesions, 31% more had regressed with the remineralizing cream than with the placebo (OR = 2.3, P = 0.04) at 12 weeks. Significantly more post-orthodontic white-spot lesions regressed with the remineralizing cream compared with a placebo over 12 weeks. Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide-amorphous calcium phosphate compared with a placebo. Forty-five participants (aged 12-18 yrs) with 408 white-spot lesions were recruited, with 23 participants randomized to the remineralizing cream and 22 to the placebo. Product was applied twice daily after fluoride toothpaste use for 12 weeks. Clinical assessments were performed according to ICDAS II criteria. Transitions between examinations were coded as progressing, regressing, or stable. Ninety-two percent of lesions were assessed as code 2 or 3. For these lesions, 31% more had regressed with the remineralizing cream than with the placebo (OR = 2.3, P = 0.04) at 12 weeks. Significantly more post-orthodontic white-spot lesions regressed with the remineralizing cream compared with a placebo over 12 weeks. Abbreviations : CPP-ACP, calcium phosphopeptide-amorphous calcium phosphate; ICDAS, International Caries Detection and Assessment System. [PUBLICATION ABSTRACT]
Author	BAILEY D. L. MANTON D. J. ADAMS G. G. TSAO C. E. HYSLOP A. MORGAN M. V. ESCOBAR K. REYNOLDS E. C.
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Keywords	remineralization clinical trial white-spot lesion CPP-ACP CPP-ACP, calcium phosphopeptide-amorphous calcium phosphate post-orthodontic ICDAS, International Caries Detection and Assessment System
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Snippet	Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population...
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SubjectTerms	Adolescent Cariostatic Agents - administration & dosage Cariostatic Agents - therapeutic use Caseins - therapeutic use Child clinical trial CPP-ACP Dental Caries - prevention & control Disease Progression Double-Blind Method Female Follow-Up Studies Humans Male Mouthwashes - therapeutic use Orthodontic Brackets - adverse effects Placebos post-orthodontic remineralization Sodium Fluoride - administration & dosage Sodium Fluoride - therapeutic use Tooth Remineralization - methods Toothpastes - therapeutic use Treatment Outcome white-spot lesion
Title	Regression of Post-orthodontic Lesions by a Remineralizing Cream
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