Regression of Post-orthodontic Lesions by a Remineralizing Cream

Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cre...

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Bibliographic Details
Published in:Journal of dental research Vol. 88; no. 12; pp. 1148 - 1153
Main Authors: Bailey, D.L., Adams, G.G., Tsao, C.E., Hyslop, A., Escobar, K., Manton, D. J., Reynolds, E.C., Morgan, M.V.
Format: Journal Article
Language:English
Published: United States SAGE Publications 01.12.2009
SAGE PUBLICATIONS, INC
Subjects:
Adolescent
Cariostatic Agents - administration & dosage
Cariostatic Agents - therapeutic use
Caseins - therapeutic use
Child
clinical trial
CPP-ACP
Dental Caries - prevention & control
Disease Progression
Double-Blind Method
Female
Follow-Up Studies
Humans
Male
Mouthwashes - therapeutic use
Orthodontic Brackets - adverse effects
Placebos
post-orthodontic
remineralization
Sodium Fluoride - administration & dosage
Sodium Fluoride - therapeutic use
Tooth Remineralization - methods
Toothpastes - therapeutic use
Treatment Outcome
white-spot lesion
remineralization
clinical trial
white-spot lesion
CPP-ACP
CPP-ACP, calcium phosphopeptide-amorphous calcium phosphate
post-orthodontic
ICDAS, International Caries Detection and Assessment System
ISSN:0022-0345, 1544-0591, 1544-0591
Online Access:Get full text
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Summary:Orthodontic patients have an increased risk of white-spot lesion formation. A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide- amorphous calcium phosphate compared with a placebo. Forty-five participants (aged 12–18 yrs) with 408 white-spot lesions were recruited, with 23 participants randomized to the remineralizing cream and 22 to the placebo. Product was applied twice daily after fluoride toothpaste use for 12 weeks. Clinical assessments were performed according to ICDAS II criteria. Transitions between examinations were coded as progressing, regressing, or stable. Ninety-two percent of lesions were assessed as code 2 or 3. For these lesions, 31% more had regressed with the remineralizing cream than with the placebo (OR = 2.3, P = 0.04) at 12 weeks. Significantly more post-orthodontic white-spot lesions regressed with the remineralizing cream compared with a placebo over 12 weeks.
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ISSN:0022-0345
1544-0591
1544-0591
DOI:10.1177/0022034509347168