How I treat Waldenström macroglobulinemia
Waldenström macroglobulinemia (WM) is an uncommon lymphoma characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M (IgM). The disease may have an asymptomatic phase, or patients may present with symptoms and complications result...
Saved in:
| Published in: | Blood Vol. 134; no. 23; p. 2022 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
05.12.2019
|
| Subjects: | |
| ISSN: | 1528-0020, 1528-0020 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Waldenström macroglobulinemia (WM) is an uncommon lymphoma characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M (IgM). The disease may have an asymptomatic phase, or patients may present with symptoms and complications resulting from marrow or other tissue infiltration, or from physicochemical or immunological properties of the monoclonal IgM. Diagnosis of WM has been clearly defined, and genetic testing for somatic mutation of MYD88L265P is a useful tool for differential diagnosis from other conditions. Specific criteria that define symptomatic disease that needs treatment offer clinical guidance. The treatment of WM has evolved rapidly, with treatment options that include anti-CD20 monoclonal antibody-based combinations and BTK inhibitors. The choice of therapy is based on the need for rapid disease control, presence of specific disease complications, and patient's age. With the use of BTK inhibitors, the use of continuous therapy has been introduced as another option over fixed-duration chemoimmunotherapy. In this review, we focus on different clinical scenarios and discuss treatment options, based on the available data. |
|---|---|
| AbstractList | Waldenström macroglobulinemia (WM) is an uncommon lymphoma characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M (IgM). The disease may have an asymptomatic phase, or patients may present with symptoms and complications resulting from marrow or other tissue infiltration, or from physicochemical or immunological properties of the monoclonal IgM. Diagnosis of WM has been clearly defined, and genetic testing for somatic mutation of MYD88L265P is a useful tool for differential diagnosis from other conditions. Specific criteria that define symptomatic disease that needs treatment offer clinical guidance. The treatment of WM has evolved rapidly, with treatment options that include anti-CD20 monoclonal antibody-based combinations and BTK inhibitors. The choice of therapy is based on the need for rapid disease control, presence of specific disease complications, and patient's age. With the use of BTK inhibitors, the use of continuous therapy has been introduced as another option over fixed-duration chemoimmunotherapy. In this review, we focus on different clinical scenarios and discuss treatment options, based on the available data. Waldenström macroglobulinemia (WM) is an uncommon lymphoma characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M (IgM). The disease may have an asymptomatic phase, or patients may present with symptoms and complications resulting from marrow or other tissue infiltration, or from physicochemical or immunological properties of the monoclonal IgM. Diagnosis of WM has been clearly defined, and genetic testing for somatic mutation of MYD88L265P is a useful tool for differential diagnosis from other conditions. Specific criteria that define symptomatic disease that needs treatment offer clinical guidance. The treatment of WM has evolved rapidly, with treatment options that include anti-CD20 monoclonal antibody-based combinations and BTK inhibitors. The choice of therapy is based on the need for rapid disease control, presence of specific disease complications, and patient's age. With the use of BTK inhibitors, the use of continuous therapy has been introduced as another option over fixed-duration chemoimmunotherapy. In this review, we focus on different clinical scenarios and discuss treatment options, based on the available data.Waldenström macroglobulinemia (WM) is an uncommon lymphoma characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M (IgM). The disease may have an asymptomatic phase, or patients may present with symptoms and complications resulting from marrow or other tissue infiltration, or from physicochemical or immunological properties of the monoclonal IgM. Diagnosis of WM has been clearly defined, and genetic testing for somatic mutation of MYD88L265P is a useful tool for differential diagnosis from other conditions. Specific criteria that define symptomatic disease that needs treatment offer clinical guidance. The treatment of WM has evolved rapidly, with treatment options that include anti-CD20 monoclonal antibody-based combinations and BTK inhibitors. The choice of therapy is based on the need for rapid disease control, presence of specific disease complications, and patient's age. With the use of BTK inhibitors, the use of continuous therapy has been introduced as another option over fixed-duration chemoimmunotherapy. In this review, we focus on different clinical scenarios and discuss treatment options, based on the available data. |
| Author | Dimopoulos, Meletios A Kastritis, Efstathios |
| Author_xml | – sequence: 1 givenname: Meletios A surname: Dimopoulos fullname: Dimopoulos, Meletios A – sequence: 2 givenname: Efstathios surname: Kastritis fullname: Kastritis, Efstathios |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31527073$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNj81KxEAQhAdZcX_07klyFCFrT0_GmRxlUXdhwYviMXQmPRKZZNb8IL6YL-CLueAKnqqK-iiouZi0sWUhziUspbR4XYYYqyWCzAHAoD4SM6nRpgAIk39-KuZ9_wYgM4X6REzVvjFg1ExcreNHskmGjmlIXihU3PZD9_3VJA25Lr6GWI6hbrmp6VQcewo9nx10IZ7v755W63T7-LBZ3W5Tl2k7pNJljozXBJU1kpmlY1aK4MaVXoMnUE6R3Wdiz5bQK2-4zLxiDRIrXIjL391dF99H7oeiqXvHIVDLcewLxBzz3KLJ9-jFAR3Lhqti19UNdZ_F3z_8Ab8DVWU |
| CitedBy_id | crossref_primary_10_1111_bjh_19706 crossref_primary_10_7759_cureus_83278 crossref_primary_10_1111_1744_9987_14094 crossref_primary_10_12998_wjcc_v10_i29_10779 crossref_primary_10_1002_hon_2982 crossref_primary_10_3389_frhem_2023_1203369 crossref_primary_10_1002_jha2_70027 crossref_primary_10_1186_s12872_025_04588_w crossref_primary_10_1002_jha2_423 crossref_primary_10_1080_10428194_2022_2131423 crossref_primary_10_1186_s13256_023_03948_4 crossref_primary_10_1038_s41375_020_01102_3 crossref_primary_10_1111_cas_14561 crossref_primary_10_1111_imm_13416 crossref_primary_10_4274_tjh_galenos_2024_2024_0132 crossref_primary_10_1186_s12967_022_03798_6 crossref_primary_10_1080_10428194_2022_2102623 crossref_primary_10_1182_bloodadvances_2021004926 crossref_primary_10_1016_j_aforl_2024_04_007 crossref_primary_10_1053_j_seminhematol_2023_03_005 crossref_primary_10_1016_j_anorl_2024_06_004 crossref_primary_10_1038_s41375_022_01732_9 crossref_primary_10_3389_fimmu_2022_1001482 crossref_primary_10_3390_ijms21093141 crossref_primary_10_1007_s00277_023_05584_w crossref_primary_10_1016_j_mayocp_2024_03_013 crossref_primary_10_1136_bcr_2023_255268 crossref_primary_10_1177_20406207221093962 crossref_primary_10_1080_17474086_2023_2270779 crossref_primary_10_3389_fimmu_2020_602868 crossref_primary_10_1111_1744_9987_13885 crossref_primary_10_3390_cancers13092055 crossref_primary_10_3390_hemato3040046 crossref_primary_10_3390_hemato3040047 crossref_primary_10_1111_bjh_19969 crossref_primary_10_7759_cureus_74144 crossref_primary_10_1111_bjh_18157 crossref_primary_10_1080_10428194_2022_2113534 crossref_primary_10_1097_HS9_0000000000000746 crossref_primary_10_1111_trf_18152 crossref_primary_10_1016_j_clml_2025_09_005 crossref_primary_10_1159_000530328 crossref_primary_10_1111_bjh_19809 crossref_primary_10_3390_medsci11040077 crossref_primary_10_1016_j_clml_2021_11_014 crossref_primary_10_3390_diagnostics11040710 crossref_primary_10_1007_s10930_022_10046_9 crossref_primary_10_3389_fgene_2022_1051917 crossref_primary_10_1200_JCO_23_02066 crossref_primary_10_1111_bjh_17138 crossref_primary_10_3390_biomedicines11041007 crossref_primary_10_1007_s12288_020_01382_w crossref_primary_10_1111_bjh_70005 crossref_primary_10_1158_1078_0432_CCR_22_2215 crossref_primary_10_1177_20406207221101697 crossref_primary_10_2147_JBM_S267938 crossref_primary_10_1002_ajh_25961 crossref_primary_10_1111_bjh_19112 crossref_primary_10_3389_fonc_2022_870258 crossref_primary_10_1016_j_hoc_2023_06_012 crossref_primary_10_1016_j_clml_2022_02_005 crossref_primary_10_1097_RLU_0000000000004362 crossref_primary_10_1182_bloodadvances_2024014190 crossref_primary_10_3390_ijms23105570 |
| ContentType | Journal Article |
| Copyright | 2019 by The American Society of Hematology. |
| Copyright_xml | – notice: 2019 by The American Society of Hematology. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1182/blood.2019000725 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Chemistry Biology Anatomy & Physiology |
| EISSN | 1528-0020 |
| ExternalDocumentID | 31527073 |
| Genre | Journal Article Review |
| GroupedDBID | --- -~X .55 0R~ 23N 2WC 34G 39C 4.4 53G 5GY 5RE 5VS 6J9 AAEDW AALRI AAXUO ABOCM ACGFO ADBBV ADVLN AENEX AFETI AFOSN AITUG AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ BAWUL BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD EX3 F5P FDB FRP GS5 GX1 H13 IH2 K-O KQ8 L7B LSO MJL N9A NPM OK1 P2P R.V RHF RHI ROL SJN THE TR2 TWZ W2D W8F WH7 WOQ WOW X7M YHG YKV 7X8 ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP EFKBS |
| ID | FETCH-LOGICAL-c458t-1c4ca7f5a0d871eee1cee33a06cbf50fa03c3a8a06aefe8a2f3f7eb4f3e5012d2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 67 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000506623900006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1528-0020 |
| IngestDate | Wed Oct 01 14:50:26 EDT 2025 Wed Feb 19 02:30:24 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 23 |
| Language | English |
| License | 2019 by The American Society of Hematology. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c458t-1c4ca7f5a0d871eee1cee33a06cbf50fa03c3a8a06aefe8a2f3f7eb4f3e5012d2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://dx.doi.org/10.1182/blood.2019000725 |
| PMID | 31527073 |
| PQID | 2292998279 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2292998279 pubmed_primary_31527073 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-12-05 20191205 |
| PublicationDateYYYYMMDD | 2019-12-05 |
| PublicationDate_xml | – month: 12 year: 2019 text: 2019-12-05 day: 05 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Blood |
| PublicationTitleAlternate | Blood |
| PublicationYear | 2019 |
| SSID | ssj0014325 |
| Score | 2.574846 |
| SecondaryResourceType | review_article |
| Snippet | Waldenström macroglobulinemia (WM) is an uncommon lymphoma characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 2022 |
| SubjectTerms | Amino Acid Substitution Bone Marrow - metabolism Bone Marrow - pathology Diagnosis, Differential Humans Immunoglobulin M - metabolism Immunotherapy Mutation, Missense Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Protein Kinase Inhibitors - therapeutic use Waldenstrom Macroglobulinemia - diagnosis Waldenstrom Macroglobulinemia - genetics Waldenstrom Macroglobulinemia - metabolism Waldenstrom Macroglobulinemia - therapy |
| Title | How I treat Waldenström macroglobulinemia |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31527073 https://www.proquest.com/docview/2292998279 |
| Volume | 134 |
| WOSCitedRecordID | wos000506623900006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEB7U-rr4aH3UFyuIByE03c1jc5JaLBVs6cFHb2Gz2QXBJtVWxT_mH_CPObtN6EkQvIQEspDszs58O_MxH8BZJLhGYJA4ITUSZhy3lGCBSeQHgacREnu22fPDbdjv8-EwGhQJt0lBqyx9onXUaS5NjrxBKQbyiNMwuhy_OEY1ylRXCwmNRagwhDLGqsPhvIrgMSu6iiGKOwYXlWVKThuWFm6YXUY0M6T-7wDTBprO5n8_cQs2CohJWjOb2IYFlVWh1srweD36JOfEkj5tNr0KK1fl3Vq7lH6rwmqvqLjX4KKbf5AbYvno5FE8o5vCd76_RmQk0IebfiKGy45DxQ7cd67v2l2n0FdwJK7A1GlKT4pQ-8JN8diklGpixGRMuIFMtO9q4TLJBMdnobTigmqmQ5V4mikf41pKd2EpyzO1DySibpoEpnEOQgIvpYLLNGVaSO6ijYSsDqfllMX4L6YoITKVv03i-aTVYW827_F41mgjZkZzF33QwR9GH8K6WU3LNPGPoKJx96pjWJbv06fJ64k1DLz2B70fVKXCJQ |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=How+I+treat+Waldenstr%C3%B6m+macroglobulinemia&rft.jtitle=Blood&rft.au=Dimopoulos%2C+Meletios+A&rft.au=Kastritis%2C+Efstathios&rft.date=2019-12-05&rft.issn=1528-0020&rft.eissn=1528-0020&rft.volume=134&rft.issue=23&rft.spage=2022&rft_id=info:doi/10.1182%2Fblood.2019000725&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1528-0020&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1528-0020&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1528-0020&client=summon |