Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist

Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome. Angiotensin‐converting enzyme (ACE) and its effector peptide angiotensin (Ang) II have been implicated in the pathogenesis of ARDS. A counter‐regulatory enzyme of ACE, ie ACE2 that degrades Ang II to Ang‐(1–7), offers a p...

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Bibliographic Details
Published in:	The Journal of pathology Vol. 225; no. 4; pp. 618 - 627
Main Authors:	Wösten-van Asperen, Roelie M, Lutter, René, Specht, Patricia A, Moll, Gert N, van Woensel, Job B, van der Loos, Chris M, van Goor, Harry, Kamilic, Jelena, Florquin, Sandrine, Bos, Albert P
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.12.2011 Wiley
Subjects:	acute lung injury Angiotensin I - pharmacology angiotensin II Angiotensin Receptor Antagonists - pharmacology angiotensin-(1-7) Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry cytokines Disease Models, Animal Intubation, Intratracheal Investigative techniques, diagnostic techniques (general aspects) Lipopolysaccharides - analysis Losartan - pharmacology Lung - drug effects Lung - pathology Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Macrophages, Alveolar - pathology Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peptide Fragments - pharmacology Peptidyl-Dipeptidase A - analysis Peptidyl-Dipeptidase A - metabolism Rats Rats, Sprague-Dawley Respiratory Distress Syndrome, Adult - chemically induced Respiratory Distress Syndrome, Adult - enzymology Respiratory Distress Syndrome, Adult - pathology Lung disease Respiratory disease Acute Cytokine acute lung injury Biological activity Heavy metal Prevention Renin angiotensin system Anatomic pathology Adult respiratory distress syndrome Lead angiotensin-(1-7) Ratio cytokines Angiotensin antagonist Angiotensin II Biological receptor
ISSN:	0022-3417, 1096-9896, 1096-9896
Online Access:	Get full text
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