Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model

Hypoxia drives kidney damage and progression of CKD. Although erythrocytes respond rapidly to hypoxia, their role and the specific molecules sensing and responding to hypoxia in CKD remain unclear. In this study, we demonstrated in a mouse model that erythrocyte ENT1-AMPD3 is a master energy regulat...

Full description

Bibliographic Details

Published in:	Journal of the American Society of Nephrology Vol. 34; no. 10; p. 1647
Main Authors:	Chen, Changhan, Xie, TingTing, Zhang, Yujin, Wang, Yiyan, Yu, Fang, Lin, Lizhen, Zhang, Weiru, Brown, Benjamin C, Zhang, Xin, Kellems, Rodney E, D'Alessandro, Angelo, Xia, Yang
Format:	Journal Article
Language:	English
Published:	United States 01.10.2023
Subjects:	Adenosine - metabolism AMP Deaminase - genetics AMP Deaminase - metabolism AMP-Activated Protein Kinases - metabolism Animals Erythrocytes - metabolism Humans Hypoxia - metabolism Mice Renal Insufficiency, Chronic - metabolism
ISSN:	1533-3450, 1533-3450
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!