Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model

Hypoxia drives kidney damage and progression of CKD. Although erythrocytes respond rapidly to hypoxia, their role and the specific molecules sensing and responding to hypoxia in CKD remain unclear. In this study, we demonstrated in a mouse model that erythrocyte ENT1-AMPD3 is a master energy regulat...

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Veröffentlicht in:	Journal of the American Society of Nephrology Jg. 34; H. 10; S. 1647
Hauptverfasser:	Chen, Changhan, Xie, TingTing, Zhang, Yujin, Wang, Yiyan, Yu, Fang, Lin, Lizhen, Zhang, Weiru, Brown, Benjamin C, Zhang, Xin, Kellems, Rodney E, D'Alessandro, Angelo, Xia, Yang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2023
Schlagworte:	Adenosine - metabolism AMP Deaminase - genetics AMP Deaminase - metabolism AMP-Activated Protein Kinases - metabolism Animals Erythrocytes - metabolism Humans Hypoxia - metabolism Mice Renal Insufficiency, Chronic - metabolism
ISSN:	1533-3450, 1533-3450
Online-Zugang:	Weitere Angaben
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