Neuroprotective effect of angiotensin II type 2 receptor stimulation in vincristine-induced mechanical allodynia

Peripheral neuropathy is the major dose-limiting side effect of many currently used chemotherapies, such as vincristine (VCR). We recently demonstrated that candesartan, an angiotensin II type 1 receptor antagonist, was neuroprotective against resiniferatoxin-induced sensory neuropathy, and that thi...

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Bibliographic Details
Published in:	Pain (Amsterdam) Vol. 159; no. 12; p. 2538
Main Authors:	Bessaguet, Flavien, Danigo, Aurore, Bouchenaki, Hichem, Duchesne, Mathilde, Magy, Laurent, Richard, Laurence, Sturtz, Franck, Desmoulière, Alexis, Demiot, Claire
Format:	Journal Article
Language:	English
Published:	United States 01.12.2018
Subjects:	Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin II Type 2 Receptor Blockers - therapeutic use Animals Antineoplastic Agents, Phytogenic - toxicity Benzimidazoles - therapeutic use Disease Models, Animal Diterpenes - toxicity Ganglia, Spinal - cytology Hyperalgesia - chemically induced Hyperalgesia - drug therapy Hyperalgesia - pathology Imidazoles - therapeutic use Male Mice Motor Activity - drug effects Neural Conduction - drug effects Neurons - metabolism Neuroprotective Agents - therapeutic use Neurotoxins - toxicity Nociception - drug effects Pyridines - therapeutic use Sciatic Nerve - pathology Sciatic Nerve - physiopathology Skin - metabolism Tetrazoles - therapeutic use Vincristine - toxicity
ISSN:	1872-6623, 1872-6623
Online Access:	Get more information
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