The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing

When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase checkpoint ensures they are stabilized and can restart. In intra-S checkpoint-deficient budding yeast, stalling forks collapse, and ∼10% form pathogenic chicken foot structures, contributing to incomplete r...

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Bibliographic Details

Published in:	Cell Vol. 149; no. 6; p. 1221
Main Authors:	Hu, Jiazhi, Sun, Lei, Shen, Fenfen, Chen, Yufei, Hua, Yu, Liu, Yang, Zhang, Mian, Hu, Yiren, Wang, Qingsong, Xu, Wei, Sun, Fei, Ji, Jianguo, Murray, Johanne M, Carr, Antony M, Kong, Daochun
Format:	Journal Article
Language:	English
Published:	United States 08.06.2012
Subjects:	Checkpoint Kinase 2 DNA Replication Epistasis, Genetic Flap Endonucleases - metabolism Genomic Instability Phosphorylation Protein Serine-Threonine Kinases - metabolism S Phase Cell Cycle Checkpoints Schizosaccharomyces - cytology Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - metabolism
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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