Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations associated with microbial abundances in a single large-scale population-based cohort of 5,959 genotyped individuals with matched gut microbial m...

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Vydáno v:Nature genetics Ročník 54; číslo 2; s. 134 - 142
Hlavní autoři: Qin, Youwen, Havulinna, Aki S., Liu, Yang, Jousilahti, Pekka, Ritchie, Scott C., Tokolyi, Alex, Sanders, Jon G., Valsta, Liisa, Brożyńska, Marta, Zhu, Qiyun, Tripathi, Anupriya, Vázquez-Baeza, Yoshiki, Loomba, Rohit, Cheng, Susan, Jain, Mohit, Niiranen, Teemu, Lahti, Leo, Knight, Rob, Salomaa, Veikko, Inouye, Michael, Méric, Guillaume
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Nature Publishing Group US 01.02.2022
Témata:
45
45/43
631/208/205/2138
631/326
692/308/174
692/699
ABO Blood-Group System - genetics
Agriculture
Animal Genetics and Genomics
Bifidobacterium - physiology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Clostridiales - physiology
Cohort Studies
Colorectal Neoplasms - genetics
Colorectal Neoplasms - microbiology
Depressive Disorder, Major - genetics
Depressive Disorder, Major - microbiology
Diet
Dietary Fiber
Enterococcus faecalis - physiology
Gastrointestinal Microbiome - genetics
Gastrointestinal Tract - microbiology
Gene Function
Genetic Variation
Genome-Wide Association Study
Host Microbial Interactions
Human Genetics
Humans
Lactase - genetics
Mediator Complex - genetics
Mendelian Randomization Analysis
Metagenome
Morganella - physiology
Polymorphism, Single Nucleotide
ISSN:1061-4036, 1546-1718, 1546-1718
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Shrnutí:Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations associated with microbial abundances in a single large-scale population-based cohort of 5,959 genotyped individuals with matched gut microbial metagenomes, and dietary and health records (prevalent and follow-up). We identified 567 independent SNP–taxon associations. Variants at the LCT locus associated with Bifidobacterium and other taxa, but they differed according to dairy intake. Furthermore, levels of Faecalicatena lactaris associated with ABO , and suggested preferential utilization of secreted blood antigens as energy source in the gut. Enterococcus faecalis levels associated with variants in the MED13L locus, which has been linked to colorectal cancer. Mendelian randomization analysis indicated a potential causal effect of Morganella on major depressive disorder, consistent with observational incident disease analysis. Overall, we identify and characterize the intricate nature of host–microbiota interactions and their association with disease. Genome-wide association analysis of gut microbial taxa in a single homogenous population-based cohort of 5,959 Finnish individuals identifies 567 independent SNP–taxon associations, including strong associations with LCT , ABO and MED13L .
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/s41588-021-00991-z