Asthma and coagulation

Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only symptomatic treatment. In recent years, our understanding of the involvement of coagulation and...

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Veröffentlicht in:Blood Jg. 119; H. 14; S. 3236
Hauptverfasser: de Boer, J Daan, Majoor, Christof J, van 't Veer, Cornelis, Bel, Elisabeth H D, van der Poll, Tom
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 05.04.2012
Schlagworte:
Administration, Inhalation
Animals
Anticoagulants - administration & dosage
Anticoagulants - therapeutic use
Asthma - complications
Asthma - drug therapy
Asthma - metabolism
Blood Coagulation - physiology
Blood Coagulation Disorders - complications
Blood Coagulation Disorders - drug therapy
Blood Coagulation Disorders - metabolism
Blood Coagulation Factors - metabolism
Blood Platelets - metabolism
Fibrinolysis
Heparin - administration & dosage
Heparin - therapeutic use
Humans
Protein C - metabolism
Receptor, PAR-2 - metabolism
Signal Transduction
ISSN:1528-0020, 1528-0020
Online-Zugang:Weitere Angaben
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Zusammenfassung:Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only symptomatic treatment. In recent years, our understanding of the involvement of coagulation and anticoagulant pathways, the fibrinolytic system, and platelets in the pathophysiology of asthma has increased considerably. Asthma is associated with a procoagulant state in the bronchoalveolar space, further aggravated by impaired local activities of the anticoagulant protein C system and fibrinolysis. Protease-activated receptors have been implicated as the molecular link between coagulation and allergic inflammation in asthma. This review summarizes current knowledge of the impact of the disturbed hemostatic balance in the lungs on asthma severity and manifestations and identifies new possible targets for asthma treatment.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1528-0020
1528-0020
DOI:10.1182/blood-2011-11-391532