Association between thyroid-stimulating hormone and blood pressure in adults: an 11-year longitudinal study
Summary Background The results of longitudinal studies on the association between thyroid function and blood pressure (BP) are divided. This study aimed to investigate this association in cross‐sectional and longitudinal settings in a nationwide, random sample representative of the Finnish adult pop...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) Jg. 84; H. 5; S. 741 - 747 |
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| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Blackwell Publishing Ltd
01.05.2016
Wiley Subscription Services, Inc |
| Schlagworte: | |
| ISSN: | 0300-0664, 1365-2265, 1365-2265 |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Summary
Background
The results of longitudinal studies on the association between thyroid function and blood pressure (BP) are divided. This study aimed to investigate this association in cross‐sectional and longitudinal settings in a nationwide, random sample representative of the Finnish adult population aged 30 and over.
Methods
The study sample was randomly drawn from the population register. A total of 5655 participants were included in the baseline analyses and 3453 in the 11‐year prospective analyses. The associations between baseline TSH and (i) BP and BP change over time; and (ii) prevalent and incident hypertension were assessed using linear and logistic models, adjusted for age, gender, smoking and body mass index.
Results
A positive association (β ± standard error) was observed between TSH and diastolic (0·36 ± 0·12, P = 0·003) but not systolic BP (0·16 ± 0·21, P = 0·45) at baseline. TSH was negatively associated with 11‐year BP change in men (systolic: −0·92 ± 0·41, P = 0·03; diastolic: −0·66 ± 0·26, P = 0·01) but not in women (P ≥ 0·09 for systolic and diastolic BP change). Participants in the highest TSH tertile within the TSH reference interval (0·4–3·4 mU/L), as compared with the lowest, had increased odds of prevalent (odds ratio 1·22, 95% confidence interval 1·05–1·43, P = 0·01) but not incident hypertension (odds ratio 0·93, 95% confidence interval 0·73–1·19, P = 0·58).
Conclusions
A modest association was found between increasing TSH and prevalent but not incident hypertension. TSH was inversely associated with BP change in men in our study. These findings contest an independent role of thyroid function at normal to near‐normal levels in the pathogenesis of hypertension. |
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| Bibliographie: | ark:/67375/WNG-PJVK6CJW-M Finnish Dental Society Local Government Pensions Institution Finnish Centre for Pensions UKK Institute for Health Promotion istex:53225EF6D28041B0FCC7772CD36AE9FA507AE57A Social Insurance Institution National Research and Development Centre for Welfare and Health Finnish Dental Association ArticleID:CEN12876 Finnish Institute for Occupational Health State Pensions Office Finnish Work Environment Fund Statistics Finland State Work Environment Fund Table S1. Association between blood pressure variables and thyroid-stimulating hormone at baseline in participants aged 65 years or less Table S2. Association between 11-year change in blood pressure variables and baseline thyroid-stimulating hormone in participants aged 65 years or less Table S3. Association between blood pressure variables and thyroid-stimulating hormone at baseline in participants aged over 65 years Table S4. Association between 11-year change in blood pressure variables and baseline thyroid-stimulating hormone in participants aged over 65 years National Public Health Institute ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ISSN: | 0300-0664 1365-2265 1365-2265 |
| DOI: | 10.1111/cen.12876 |