Clinically deployable Kinesia™ technology for automated tremor assessment

The objective was to design, build, and assess Kinesia™, a wireless system for automated assessment of Parkinson's disease (PD) tremor. The current standard in evaluating PD is the Unified Parkinson's Disease Rating Scale (UPDRS), a qualitative ranking system typically completed during an...

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Podrobná bibliografia
Vydané v:	Movement disorders Ročník 24; číslo 5; s. 723 - 730
Hlavní autori:	Giuffrida, Joseph P., Riley, David E., Maddux, Brian N., Heldman, Dustin A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.04.2009 Wiley
Predmet:	Algorithms Automatic Data Processing - methods Biological and medical sciences Humans Kinesia Kinesics Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Parkinson Disease - complications Parkinson's disease Severity of Illness Index tremor Tremor - diagnosis Tremor - etiology UPDRS Nervous system diseases Parkinson's disease Tremor Parkinson disease Kinesia Involuntary movement Cerebral disorder Technology Central nervous system disease UPDRS Degenerative disease Neurological disorder Extrapyramidal syndrome
ISSN:	0885-3185, 1531-8257, 1531-8257
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Popis
Shrnutí:	The objective was to design, build, and assess Kinesia™, a wireless system for automated assessment of Parkinson's disease (PD) tremor. The current standard in evaluating PD is the Unified Parkinson's Disease Rating Scale (UPDRS), a qualitative ranking system typically completed during an office visit. Kinesia integrates accelerometers and gyroscopes in a compact patient‐worn unit to capture kinematic movement disorder features. Objectively quantifying PD manifestations with increased time resolution should aid in evaluating efficacy of treatment protocols and improve patient management. In this study, PD subjects performed the tremor subset of the UPDRS motor section while wearing Kinesia. Quantitative kinematic features were processed and highly correlated to clinician scores for rest tremor (r2 = 0.89), postural tremor (r2 = 0.90), and kinetic tremor (r2 = 0.69). The quantitative features were used to develop a mathematical model that predicted tremor severity scores for new data with low errors. Finally, PD subjects indicated high clinical acceptance. © 2009 Movement Disorder Society
Bibliografia:	National Institute of Neurological Disorders and Stroke Potential conflict of interest: Dr. Giuffrida and Dr. Heldman are employess of CleveMed. Phase II SBIR - No. 5R44NS043816-03 ark:/67375/WNG-2J9KJGDQ-R National Institutes of Health ArticleID:MDS22445 istex:5E3ECD49515AA95782467635A7EEFFE83BEF1245 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0885-3185 1531-8257 1531-8257
DOI:	10.1002/mds.22445