BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS [version 1; peer review: 3 approved]

Lipidomics increasingly describes the quantitation using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due to...

Full description

Saved in:
Bibliographic Details
Published in:F1000 research Vol. 10; p. 4
Main Authors: Gaud, Caroline, C. Sousa, Bebiana, Nguyen, An, Fedorova, Maria, Ni, Zhixu, O'Donnell, Valerie B, Wakelam, Michael J.O, Andrews, Simon, Lopez-Clavijo, Andrea F
Format: Journal Article
Language:English
Published: England F1000 Research Ltd 2021
Subjects:
Biosynthetic pathway analysis
Lipidomics
lipids
lipid profiling
LIPID MAPS
ISSN:2046-1402, 2046-1402
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lipidomics increasingly describes the quantitation using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due to biological differences often encompass large numbers of structurally-related lipids, with these being regulated by enzymes from well-known metabolic pathways.  As lipidomics datasets increase in complexity, the interpretation of their results becomes more challenging.  BioPAN addresses this by enabling the researcher to visualise quantitative lipidomics data in the context of known biosynthetic pathways.  BioPAN provides a list of genes, which could be involved in the activation or suppression of enzymes catalysing lipid metabolism in mammalian tissues.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.28022.1