BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS [version 1; peer review: 3 approved]

Lipidomics increasingly describes the quantitation using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due to...

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Vydáno v:F1000 research Ročník 10; s. 4
Hlavní autoři: Gaud, Caroline, C. Sousa, Bebiana, Nguyen, An, Fedorova, Maria, Ni, Zhixu, O'Donnell, Valerie B, Wakelam, Michael J.O, Andrews, Simon, Lopez-Clavijo, Andrea F
Médium: Journal Article
Jazyk:angličtina
Vydáno: England F1000 Research Ltd 2021
Témata:
Biosynthetic pathway analysis
Lipidomics
lipids
lipid profiling
LIPID MAPS
ISSN:2046-1402, 2046-1402
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Shrnutí:Lipidomics increasingly describes the quantitation using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due to biological differences often encompass large numbers of structurally-related lipids, with these being regulated by enzymes from well-known metabolic pathways.  As lipidomics datasets increase in complexity, the interpretation of their results becomes more challenging.  BioPAN addresses this by enabling the researcher to visualise quantitative lipidomics data in the context of known biosynthetic pathways.  BioPAN provides a list of genes, which could be involved in the activation or suppression of enzymes catalysing lipid metabolism in mammalian tissues.
Bibliografie:ObjectType-Article-1
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ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.28022.1