Regulation of lipid peroxidation and ferroptosis in diverse species

Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and...

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Veröffentlicht in:Genes & development Jg. 32; H. 9-10; S. 602
Hauptverfasser: Conrad, Marcus, Kagan, Valerian E, Bayir, Hülya, Pagnussat, Gabriela C, Head, Brian, Traber, Maret G, Stockwell, Brent R
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.05.2018
Schlagworte:
Animals
Antioxidants - metabolism
Biological Evolution
Cell Death - physiology
Humans
Iron - metabolism
Lipid Peroxidation
Reactive Oxygen Species - metabolism
Species Specificity
iron
ferroptosis
cell death
lipid peroxidation
ROS
vitamin E
ISSN:1549-5477, 1549-5477
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Zusammenfassung:Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1549-5477
1549-5477
DOI:10.1101/gad.314674.118