The Evolving Complexity of the Podocyte Cytoskeleton

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental sti...

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Vydané v:Journal of the American Society of Nephrology Ročník 28; číslo 11; s. 3166
Hlavní autori: Schell, Christoph, Huber, Tobias B
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.11.2017
Predmet:
Cytoskeleton - genetics
Cytoskeleton - physiology
Cytoskeleton - ultrastructure
Female
Humans
Male
Podocytes - physiology
glomerular disease
cytoskeleton
nephrotic syndrome
podocyte
ISSN:1533-3450, 1533-3450
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Popis
Shrnutí:Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1533-3450
1533-3450
DOI:10.1681/ASN.2017020143