The Evolving Complexity of the Podocyte Cytoskeleton

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental sti...

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Veröffentlicht in:Journal of the American Society of Nephrology Jg. 28; H. 11; S. 3166
Hauptverfasser: Schell, Christoph, Huber, Tobias B
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.11.2017
Schlagworte:
Cytoskeleton - genetics
Cytoskeleton - physiology
Cytoskeleton - ultrastructure
Female
Humans
Male
Podocytes - physiology
glomerular disease
cytoskeleton
nephrotic syndrome
podocyte
ISSN:1533-3450, 1533-3450
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Zusammenfassung:Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.
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ISSN:1533-3450
1533-3450
DOI:10.1681/ASN.2017020143