Exploring the Molecular Aetiology of Preeclampsia by Massive Parallel Sequencing of DNA

Purpose of Review This manuscript aims to review (for the first time) studies describing NGS sequencing of preeclampsia (PE) women’s DNA. Recent Findings Describing markers for the early detection of PE is an essential task because, although associated molecular dysfunction begins early on during pr...

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Veröffentlicht in:Current hypertension reports Jg. 22; H. 4; S. 31
Hauptverfasser: Laissue, Paul, Vaiman, Daniel
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Springer US 01.04.2020
Springer Nature B.V
Current Medicine Group
Schlagworte:
Bioinformatics
Biomarkers
Cardiology
Cell cycle
Deoxyribonucleic acid
Disease
DNA
DNA methylation
Etiology
Family Medicine
Gene expression
General Practice
Genetics
Genomes
Genomics
Hematology
Hypertension
Hypoxia
Internal Medicine
Life Sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Mutation
Nephrology
Preeclampsia
Preeclampsia (VD Garovic
Pregnancy
Primary Care Medicine
Reproductive Biology
Section Editor
Sexual reproduction
Topical Collection on Preeclampsia
Genetic biomarker
Preeclampsia
Next-generation sequencing (NGS)
Molecular medicine
ISSN:1522-6417, 1534-3111, 1534-3111
Online-Zugang:Volltext
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Zusammenfassung:Purpose of Review This manuscript aims to review (for the first time) studies describing NGS sequencing of preeclampsia (PE) women’s DNA. Recent Findings Describing markers for the early detection of PE is an essential task because, although associated molecular dysfunction begins early on during pregnancy, the disease’s clinical signs usually appear late in pregnancy. Although several biochemical biomarkers have been proposed, their use in clinical environments is still limited, thereby encouraging research into PE’s genetic origin. Hundreds of genes involved in numerous implantation- and placentation-related biological processes may be coherent candidates for PE aetiology. Next-generation sequencing (NGS) offers new technical possibilities for PE studying, as it enables large genomic regions to be analysed at affordable cost. This technique has facilitated the description of genes contributing to the molecular origin of a significant amount of monogenic and complex diseases. Regarding PE, NGS of DNA has been used in familial and isolated cases, thereby enabling new genes potentially related to the phenotype to be proposed. Summary For a better understanding of NGS, technical aspects, applications and limitations are presented initially. Thereafter, NGS studies of DNA in familial and non-familial cases are described, including pitfalls and positive findings. The information given here should enable scientists and clinicians to analyse and design new studies permitting the identification of novel clinically useful molecular PE markers.
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ISSN:1522-6417
1534-3111
1534-3111
DOI:10.1007/s11906-020-01039-z