Understanding Ethanol Tolerance Mechanism in Saccharomyces cerevisiae to Enhance the Bioethanol Production: Current and Future Prospects

The commercial production of bioethanol from lignocellulosic biomass is challenged by the repression of cell growth and compromised fermentation conditions. However, employing Saccharomyces cerevisiae is an economically feasible process resulting in the effective conversion of fermentable sugars to...

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Vydáno v:	Bioenergy research Ročník 14; číslo 2; s. 670 - 688
Hlavní autoři:	Jhariya, Upasana, Dafale, Nishant A., Srivastava, Shweta, Bhende, Rahul S., Kapley, Atya, Purohit, Hemant J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.06.2021 Springer Springer Nature B.V
Témata:	Acetaldehyde Alcohol Alcohol dehydrogenase Alcohol, Denatured bioethanol Biofuels Bioinformatics biomass Biomedical and Life Sciences cell growth economic feasibility Ethanol ethanol production Fermentation Fungi Genes Inhibitors Life Sciences Lignocellulose Physiological aspects Plant Breeding/Biotechnology Plant Ecology Plant Genetics and Genomics Plant Sciences Saccharomyces cerevisiae Sugar Wood Science & Technology Yeast zinc Zinc finger proteins Transcription factors Bioethanol Alcohol dehydrogenase Ethanol tolerance Inhibitor tolerance
ISSN:	1939-1234, 1939-1242
On-line přístup:	Získat plný text
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Shrnutí:	The commercial production of bioethanol from lignocellulosic biomass is challenged by the repression of cell growth and compromised fermentation conditions. However, employing Saccharomyces cerevisiae is an economically feasible process resulting in the effective conversion of fermentable sugars to bioethanol. S. cerevisiae’s high productive feature is contributed by robust alcohol dehydrogenase and the ability to tolerate various stresses during the fermentation process. The present review employs various bioinformatics pipeline to assess the structural insights of ADH and interaction among the tolerance genes. Docking of S. cerevisiae’s ADH interaction shows the high binding affinity of − 2.81 Kcal/mol with acetaldehyde contributed by four zinc fingers. In inhibitor tolerance capacity of S. cerevisiae was explored. The STRING platform sheds light on the mechanism and interaction of ASR1 and other stress-responsive elements playing a pivotal role in ethanol tolerance. The stress-responsive genes such as HSPs and MSN2/4 provide balanced physiology under various stress conditions. The present review unravels the complex mechanism behind the inhibitor and ethanol tolerance, directing to several bottlenecks for the improvisation of S. cerevisiae’s performance.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1939-1234 1939-1242
DOI:	10.1007/s12155-020-10228-2