Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb-repressive complex 1 (PRC1) family complexes are central to maintaining this repression. These include a set of canonical PRC1 complexes, each of which c...

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Veröffentlicht in:	Genes & development Jg. 33; H. 13-14; S. 799
Hauptverfasser:	Plys, Aaron J, Davis, Christopher P, Kim, Jongmin, Rizki, Gizem, Keenen, Madeline M, Marr, Sharon K, Kingston, Robert E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2019
Schlagworte:	Animals Cell Line Escherichia coli - genetics Gene Expression Regulation, Developmental - genetics Mice Mice, Inbred C57BL NIH 3T3 Cells Organelles - metabolism Point Mutation Polycomb Repressive Complex 1 - chemistry Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Protein Domains Sf9 Cells gene repression development phase separation PRC1 Polycomb-repressive complex nucleosome compaction chromatin
ISSN:	1549-5477, 1549-5477
Online-Zugang:	Weitere Angaben
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