Cellular Origin and Functional Relevance of Collagen I Production in the Kidney

Interstitial fibrosis is associated with chronic renal failure. In addition to fibroblasts, bone marrow-derived cells and tubular epithelial cells have the capacity to produce collagen. However, the amount of collagen produced by each of these cell types and the relevance of fibrosis to renal functi...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology Vol. 29; no. 7; p. 1859
Main Authors: Buchtler, Simone, Grill, Alexandra, Hofmarksrichter, Stefanie, Stöckert, Petra, Schiechl-Brachner, Gabriela, Rodriguez Gomez, Manuel, Neumayer, Sophia, Schmidbauer, Kathrin, Talke, Yvonne, Klinkhammer, Barbara M, Boor, Peter, Medvinsky, Alexander, Renner, Kerstin, Castrop, Hayo, Mack, Matthias
Format: Journal Article
Language:English
Published: United States 01.07.2018
Subjects:
Acute Kidney Injury - etiology
Acute Kidney Injury - metabolism
Acute Kidney Injury - pathology
Acute Kidney Injury - physiopathology
Adenine
Animals
Bone Marrow Cells - metabolism
Cell Lineage
Collagen Type I - genetics
Collagen Type I - metabolism
Epithelial Cells - metabolism
Female
Fibroblasts - metabolism
Fibrosis
Glomerular Filtration Rate
Hematopoiesis
Kidney - pathology
Kidney - physiopathology
Kidney Tubules - cytology
Mice
Mice, Knockout
Renal Insufficiency, Chronic - chemically induced
Renal Insufficiency, Chronic - metabolism
Renal Insufficiency, Chronic - pathology
Renal Insufficiency, Chronic - physiopathology
Ureteral Obstruction - complications
chronic kidney disease
fibrosis
interstitial fibrosis
chronic renal failure
immunology
ISSN:1533-3450, 1533-3450
Online Access:Get more information
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Summary:Interstitial fibrosis is associated with chronic renal failure. In addition to fibroblasts, bone marrow-derived cells and tubular epithelial cells have the capacity to produce collagen. However, the amount of collagen produced by each of these cell types and the relevance of fibrosis to renal function are unclear. We generated conditional cell type-specific collagen I knockout mice and used (reversible) unilateral ureteral obstruction and adenine-induced nephropathy to study renal fibrosis and function. In these mouse models, hematopoietic, bone marrow-derived cells contributed to 38%-50% of the overall deposition of collagen I in the kidney. The influence of fibrosis on renal function was dependent on the type of damage. In unilateral ureteral obstruction, collagen production by resident fibroblasts was essential to preserve renal function, whereas in the chronic model of adenine-induced nephropathy, collagen production was detrimental to renal function. Our data show that hematopoietic cells are a major source of collagen and that antifibrotic therapies need to be carefully considered depending on the type of disease and the underlying cause of fibrosis.
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ISSN:1533-3450
1533-3450
DOI:10.1681/ASN.2018020138