Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

In a placebo-controlled, phase 2–3 trial, one dose of mRNA-1345 led to a lower incidence of RSV disease among adults 60 years of age or older. Solicited local and systemic adverse reactions occurred more often with the vaccine.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine Jg. 389; H. 24; S. 2233 - 2244
Hauptverfasser:	Wilson, Eleanor, Goswami, Jaya, Baqui, Abdullah H., Doreski, Pablo A., Perez-Marc, Gonzalo, Zaman, Khalequ, Monroy, Jorge, Duncan, Christopher J.A., Ujiie, Mugen, Rämet, Mika, Pérez-Breva, Lina, Falsey, Ann R., Walsh, Edward E., Dhar, Rakesh, Wilson, Lauren, Du, Jiejun, Ghaswalla, Parinaz, Kapoor, Archana, Lan, Lan, Mehta, Shraddha, Mithani, Runa, Panozzo, Catherine A., Simorellis, Alana K., Kuter, Barbara J., Schödel, Florian, Huang, Wenmei, Reuter, Caroline, Slobod, Karen, Stoszek, Sonia K., Shaw, Christine A., Miller, Jacqueline M., Das, Rituparna, Chen, Grace L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Massachusetts Medical Society 14.12.2023
Schlagworte:	Aged Aging Aging General Antibodies, Viral Chronic obstructive pulmonary disease Clinical Medicine Clinical Medicine General Clinical trials Confidence intervals Critical Care Critical Care General Double-Blind Method Geriatrics Glycoproteins Humans Infections Infectious Disease Infectious Disease General Middle Aged Morbidity mRNA mRNA Vaccines - adverse effects mRNA Vaccines - therapeutic use Older people Outpatient-Based Clinical Medicine Placebos Product development Pulmonary Respiratory diseases Respiratory syncytial virus Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Vaccines - adverse effects Respiratory Syncytial Virus Vaccines - therapeutic use Respiratory Syncytial Virus, Human - genetics Respiratory tract diseases Respiratory Tract Diseases - diagnosis Respiratory Tract Diseases - epidemiology Respiratory Tract Diseases - prevention & control Safety Side effects Statistical analysis Success Treatment Outcome Vaccine efficacy Vaccines Viral Infections
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!