Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI

The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in schizophrenia has given prominence to its importance in studies on the dysconnection associated with schizophrenia. Abnormal functional connectivities of the DLPFC have been found...

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Bibliographic Details
Published in:Neuroscience letters Vol. 417; no. 3; pp. 297 - 302
Main Authors: Zhou, Yuan, Liang, Meng, Jiang, Tianzi, Tian, Lixia, Liu, Yong, Liu, Zhening, Liu, Haihong, Kuang, Fan
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 07.05.2007
Elsevier
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain - pathology
Brain - physiopathology
Brain Mapping - methods
Connectivity
Dorsolateral prefrontal cortex
Female
fMRI
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging - methods
Male
Medical sciences
Nerve Net - pathology
Nerve Net - physiopathology
Neural Pathways - pathology
Neural Pathways - physiopathology
Predictive Value of Tests
Prefrontal Cortex - pathology
Prefrontal Cortex - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Resting state
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Vertebrates: nervous system and sense organs
Dorsolateral prefrontal cortex
Schizophrenia
fMRI
Connectivity
Resting state
Psychosis
Central nervous system
Prefrontal cortex
Nuclear magnetic resonance imaging
Encephalon
Functional imaging
ISSN:0304-3940, 1872-7972
Online Access:Get full text
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Summary:The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in schizophrenia has given prominence to its importance in studies on the dysconnection associated with schizophrenia. Abnormal functional connectivities of the DLPFC have been found during various goal-directed tasks; however, the occurrence of the abnormality during rest in patients with schizophrenia has rarely been reported. In the present study, we selected bilateral Brodmann's area 46 as region of interest and analyzed the differences in the DLPFC functional connectivity pattern between 17 patients with first-episode schizophrenia (FES) and 17 matched controls using resting-state fMRI. We found that the bilateral DLPFC showed reduced functional connectivities to the parietal lobe, posterior cingulate cortex, thalamus and striatum in FES patients. We also found enhanced functional connectivity between the left DLPFC and the left mid-posterior temporal lobe and the paralimbic regions in FES patients. Our results suggest that functional dysconnectivity associated with the DLPFC exists in schizophrenia during rest. This may be partially related to disturbance in the intrinsic brain activity.
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ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2007.02.081