Preoperative Treatment of Locally Advanced Rectal Cancer

In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy.

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Podrobná bibliografie
Vydáno v:	The New England journal of medicine Ročník 389; číslo 4; s. 322 - 334
Hlavní autoři:	Schrag, Deborah, Shi, Qian, Weiser, Martin R., Gollub, Marc J., Saltz, Leonard B., Musher, Benjamin L., Goldberg, Joel, Al Baghdadi, Tareq, Goodman, Karyn A., McWilliams, Robert R., Farma, Jeffrey M., George, Thomas J., Kennecke, Hagen F., Shergill, Ardaman, Montemurro, Michael, Nelson, Garth D., Colgrove, Brian, Gordon, Vallerie, Venook, Alan P., O’Reilly, Eileen M., Meyerhardt, Jeffrey A., Dueck, Amylou C., Basch, Ethan, Chang, George J., Mamon, Harvey J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Massachusetts Medical Society 27.07.2023
Témata:	5-Fluorouracil Adult Anal Canal - surgery Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Cancer therapies Chemoradiotherapy Chemoradiotherapy - adverse effects Chemoradiotherapy - methods Chemotherapy Chemotherapy, Adjuvant Colorectal cancer Death Disease-Free Survival Fluorouracil - administration & dosage Fluorouracil - adverse effects Gastroenterology Gastrointestinal Tract Cancer Hematology Humans Leucovorin - administration & dosage Leucovorin - adverse effects Neoadjuvant Therapy Neoplasm Recurrence, Local - drug therapy Neoplasm Staging Oncology Organ Sparing Treatments Organoplatinum Compounds Oxaliplatin Oxaliplatin - administration & dosage Oxaliplatin - adverse effects Pathology Patients Pelvis Preoperative Care Preoperative Period Radiation therapy Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - surgery Rectum Review boards Sphincter Statistical analysis Surgeons Surgery Survival Treatments in Oncology Tumors
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line přístup:	Získat plný text
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Popis
Shrnutí:	In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2303269